32(02) 113-118 
| Relationship of Oxidative Stress in Hepatitis B Infection Activity with HBV DNA and Fibrosis |
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| Fazilet Duygu, M.D.¹, Hasan Karsen, M.D.², Nurten Aksoy, M.D.³, and Abdullah Taskin, M.D.³ | | Department of Infectious Disease and Clinic Microbiology1, Tokat State Hospital, Tokat; Department of Infectious Disease and Clinic Microbiology2, Faculty of
Medicine, Harran University, Sanliurfa; ³Department of Biochemistry3, Faculty of Medicine, Harran University, Sanliurfa,Turkey | |
| Background: The aim of this study was to evaluate oxidative stress in various clinical forms
of hepatitis B infection and to investigate its role in the development of the chronic form of
the disease.
Methods: Ninety-three patients with inactive hepatitis B surface antigen (HbsAg) carrier
state (IHBCS), 65 patients with chronic hepatitis B infection (CHB), and 42 healthy adults
were included in the study. The following values were measured and compared in patient
groups: total antioxidant status (TAS), total oxidative stress (TOS), oxidative stress index
(OSI), sulfhydryl (SH), lipid peroxidation (LOOH), catalase (CAT), and ceruloplasmin. In
patients with chronic hepatitis B, these values were compared with HBV DNA and fibrosis
levels.
Results: ALT, TOS, LOOH, and OSI levels were higher in the CHB group compared to the
other groups (P <0.001). Catalase levels increased in the CHB and IHBCS groups compared
to the control group (P <0.001). Total aminooxidant and ceruloplasmin levels were found
to be lowest in the CHB group and highest in the control group (P <0.001). Sulfhyrdyl was
higher in the control group compared to the other groups (P <0.001). In the CHB group,
there was no correlation between the HBV DNA and OSI (P >0.05).
Conclusions: These finding suggested that oxidative stress is associated with hepatitis B
activity. |
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2012 Mar; 32(02) 113-118 |
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| DOI : http://dx.doi.org/10.3343/alm.2012.32.2.113 |
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| Keyword : Hepatitis B, HBV DNA, Fibrosis, Oxidative stress, Catalase, Sulfhydryl |
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