32(03) 225-228 
| The First Korean Case of Candidemia due to Candida dubliniensis |
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| Nae Yu, M.D., Hye Ryoun Kim, M.D., and Mi-Kyung Lee, M.D. | | Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea | |
| Candidemia due to uncommon Candida spp. appears to be increasing in incidence. C.
dubliniensis has been increasingly recovered from individuals not infected with HIV. Identification
of C. dubliniensis can be problematic in routine clinical practice due to its phenotypic
resemblance to C. albicans. We report the first case of C. dubliniensis candidemia
in Korea, which occurred in a 64-yr-old woman who presented with partial seizure, drowsiness,
and recurrent fever. Germ-tube positive yeast that was isolated from blood and central
venous catheter tip cultures formed smooth, white colonies on sheep blood agar and
Sabouraud agar plates, indicative of Candida spp. C. dubliniensis was identified using the
Vitek 2 system (bioMerieux, USA), latex agglutination, chromogenic agar, and multiplex
PCR. The blood isolate was susceptible to flucytosine, fluconazole, voriconazole, and amphotericin
B. After removal of the central venous catheter and initiation of fluconazole
treatment, the patient’s condition gradually improved, and she was cleared for discharge
from our hospital. Both clinicians and microbiologists should be aware of predisposing
factors to C. dubliniensis candidemia in order to promote early diagnosis and appropriate
treatment. |
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2012 May; 32(03) 225-228 |
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| DOI : http://dx.doi.org/10.3343/alm.2012.32.3.225 |
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| Keyword : Candida dubliniensis, Candidemia, Latex agglutination, Multiplex PCR |
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