Ann Lab Med 2017; 37(5): 371-380  
Accuracy Assessment of Five Equations Used for Estimating the Glomerular Filtration Rate in Korean Adults
Tae-Dong Jeong, M.D.1, Eun-Jung Cho, M.D.2, Woochang Lee, M.D.2, Sail Chun, M.D.2, Ki-Sook Hong, M.D.1, and Won-Ki Min, M.D.2
Department of Laboratory Medicine1, College of Medicine, Ewha Womans University, Seoul; Department of Laboratory Medicine2, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea
Correspondence to: Won-Ki Min
Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea
Tel: +82-2-3010-4503 Fax: +82-2-478-0884 E-mail: wkmin@amc.seoul.kr
Received: December 18, 2016; Revised: February 8, 2017; Accepted: May 15, 2017; Published online: September 1, 2017.
© The Korean Society for Laboratory Medicine. All rights reserved.

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Abstract
Background: We aimed to assess the performance of the five creatinine-based equations commonly used for estimates of the glomerular filtration rate (eGFR), namely, the creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPIcr), Asian CKD-EPI, revised Lund–Malmö (revised LM), full age spectrum (FAS), and Korean FAS equations, in the Korean population.
Methods: A total of 1,312 patients, aged 20 yr and above who underwent 51Cr-EDTA GFR measurements (mGFR), were enrolled. The bias (eGFR–mGFR) and precision (root mean square error [RMSE]) were calculated. The accuracy (P30) of four eGFR equations was compared to that of the CKD-EPIcr equation. P30 was defined as the percentage of patients whose eGFR was within±30% of the mGFR.
Results: The mean bias (mL·min-1·1.73 m-2) of the five eGFR equation was as follows: CKD-EPIcr, –0.6; Asian CKD-EPI, 2.7; revised LM, –6.5; FAS, –2.5; and Korean FAS, –0.2. The bias of the Asian CKD-EPI, revised LM, and FAS equations showed a significant difference from zero (P<0.001). The RMSE values were as follows: CKD-EPIcr, 15.6; Asian CKD-EPI, 15.6; revised LM, 17.9; FAS, 16.3; and Korean FAS, 15.8. There were no significant differences in the P30 except for the Asian CKD-EPI equation: CKD-EPIcr, 76.6%; Asian CKD-EPI, 74.7%; revised LM, 75.8%; FAS, 76.0%; and Korean FAS, 75.8%.
Conclusions: The CKD-EPIcr and Korean FAS equations showed equivalent analytical and clinical performances in the Korean adult population.
Keywords: Accuracy, Comparison, Creatinine, Equation, Glomerular filtration rate


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