Ann Lab Med 2018; 38(5): 431-439  
Postprandial Lipid Concentrations and Daytime Biological Variation of Lipids in a Healthy Chinese Population
Dagan Yang, M.S.1*, Qian Cai, B.S.2*, Xinglun Qi, B.S.1, and Yunxian Zhou, Ph.D.2
Department of Laboratory Medicine1, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; School of Nursing2, Zhejiang Chinese Medical University, Hangzhou, China
Corresponding author: Yunxian Zhou
https://orcid.org/0000-0002-5419-5937
School of Nursing, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou 310053, China
Tel: +86-571-86613676
Fax: +86-571-86613674
E-mail: yunxianzhou@hotmail.com
*These authors contributed equally to this work.
Received: July 18, 2017; Revised: December 28, 2017; Accepted: May 4, 2018; Published online: September 1, 2018.
© Korean Society for Laboratory Medicine. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Several latest guidelines and consensus statements from Europe and the United States specify that there is no need for fasting prior to routine lipid tests. However, the latest Chinese guidelines still recommend fasting tests owing to a lack of local evidence. This study aimed to investigate postprandial lipid concentrations and daytime biological variation of lipids in a healthy Chinese population.
Methods: Venous blood samples were collected from 41 ostensibly healthy Chinese volunteers at five time points during the day (06:30, 09:00, 12:00, 15:00, and 18:30). The same batch of reagents was used to determine lipid concentrations. A nested ANOVA was performed to calculate within-subject biological variation (CVI) and between-subject biological variation (CVG).
Results: Postprandial concentrations of triglyceride were higher than fasting concentrations, with the maximum change occurring at 12:00 (0.5 hours after lunch, 0.21±0.65 mmol/L difference). The daytime biological variation of triglycerides was relatively high (CVI=25%, CVG=35.9%). The postprandial concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein A1, and apolipoprotein B were mostly lower than the fasting concentrations, and their daytime biological variations were relatively low (CVI=2.4-4.4%, CVG=11.8-18.7%).
Conclusions: As most daytime lipid concentrations changed only slightly, non-fasting samples could be used for routine lipid tests. However, in cases of abnormal postprandial triglyceride concentrations, dietary factors and fasting time should be considered when interpreting the results.
Keywords: Biological variation, Postprandial lipids, Triglyceride, Fasting, Non-fasting



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