Ann Lab Med 2019; 39(1): 76-80  https://doi.org/10.3343/alm.2019.39.1.76
Role of Salivary Immune Parameters in Patients With Primary Sjögren’s Syndrome
Yu-Hung Hung, M.Sc.1, Yung-Hung Lee, B.S.1, Pei-Pei Chen, M.Sc.2, Yuan-Zhao Lin, M.Sc.2, Chia-Hui Lin, M.Sc.2, and Jeng-Hsien Yen, M.D., Ph.D.2,3
1Department of Laboratory Medicine, 2Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, and 3Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Taiwan
Corresponding author: Jeng-Hsien Yen, M.D.
https://orcid.org/0000-0002-1291-1739
Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, NO. 100, Tzyou 1st Road Kaohsiung 807, Taiwan
Tel: +886-7-3121101 #6088
Fax: +886-7-3221505
E-mail: jehsye@kmu.edu.tw
Received: December 27, 2017; Revised: March 31, 2018; Accepted: August 20, 2018; Published online: January 1, 2019.
© Korean Society for Laboratory Medicine. All rights reserved.

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Abstract
Background: Several factors, including clinical manifestations and laboratory data, have been used to evaluate the disease activity of Sjögren’s syndrome (SS). We investigated saliva indicators of disease activity in primary SS patients.
Methods: We enrolled 138 Taiwanese patients with primary SS and 100 Taiwanese normal controls. Interleukin (IL)-6, IL-17A, tumor necrosis factor-alpha (TNF-α), and rheumatoid factor (RF)-IgA levels in saliva samples were measured using ELISA or fluorescent enzyme-linked immunoassay. Serum IgG, IgA, and IgM levels were measured by nephelometry. Erythrocyte sedimentation rate (ESR) was measured with an automatic ESR analyzer. The t-test and Pearson correlation test were used.
Results: IL-6 level was higher in primary SS patients than in normal controls (14.23±14.77 vs 9.87±7.32, P=0.012), but there were no significant differences in IL-17A, TNF-α, and RF-IgA levels. In primary SS patients, IL-6 level correlated weakly with ESR and IgG levels (r=0.252, P=0.015, and r=0.248, P=0.017, respectively), and TNF-α level correlated weakly with IgG level (r=0.231, P=0.024).
Conclusions: IL-6 may play a role in SS pathogenesis. Saliva IL-6 might be an indicator of disease activity in primary SS patients.
Keywords: Sjögren’s syndrome, Saliva, Interleukin-6, Interleukin-17A, Tumor necrosis factor-alpha, Rheumatoid factor-IgA



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