Ann Lab Med 2019; 39(3): 322-326  https://doi.org/10.3343/alm.2019.39.3.322
Age-Specific Cutoffs of the Sysmex UF-1000i Automated Urine Analyzer for Rapid Screening of Urinary Tract Infections in Outpatients
Hyunji Kim, M.D.1, Hye Ryoun Kim, M.D., Ph.D.1, Tae-Hyoung Kim, M.D., Ph.D.2, and Mi-Kyung Lee , M.D., Ph.D.1
Departments of 1Laboratory Medicine and 2Urology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea
Corresponding author: Mi-Kyung Lee, M.D., Ph.D. https://orcid.org/0000-0003-1824-476X
Department of Laboratory Medicine, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul 06973, Korea
Tel: +82-2-6299-2719
Fax: +82-2-6298-8630
E-mail: cpworld@cau.ac.kr
Received: June 25, 2018; Revised: August 29, 2018; Accepted: December 11, 2018; Published online: May 1, 2019.
© Korean Society for Laboratory Medicine. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
We investigated the usefulness of age-specific cutoffs for screening of urinary tract infections (UTIs) in Korean outpatients, using the automated urine analyzer UF-1000i (Sysmex, Kobe, Japan). We retrospectively reviewed outpatient medical records. Urine samples of 7,443 outpatients from January 2010 to December 2017 were analyzed using urine culture and UF-1000i. ROC curves were calculated for each UF-1000i parameter based on the culture results. There were 1,398 culture positive samples, 5,774 culture negative samples, and 271 contaminated samples. UF-1000i had an area under the curve of ≥0.9 in outpatients >15 years. The appropriate cutoffs, which are the sum of bacterial (B-A-C) and white blood cell (WBC) counts, were 297.10/μL (15–24 years), 395.65/μL (25–44 years), 135.65/μL (45–64 years), 67.95/μL (65–74 years), and 96.5/μL (≥75 years). B-A-C and WBC counts differed among the three most frequently identified bacteria (Escherichia coli, Klebsiella pneumoniae, and Enterococcus faecalis). The UF-1000i system is useful for applying age-specific cutoffs to screen for UTIs, thereby preventing antibiotic abuse and reducing antibiotic resistance. Future studies can explore how its B-A-C and WBC counts can facilitate selection of empirical antibiotics by distinguishing between gram-positive and gram-negative bacteria.
Keywords: UF-1000i, Urinary tract infection, Age-specific cutoff, Outpatients



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