Ann Lab Med 2019; 39(3): 278-283  https://doi.org/10.3343/alm.2019.39.3.278
Comparison of Clinical Performance Between BacT/Alert Virtuo and BacT/Alert 3D Blood Culture Systems
Seong Chun Kim, M.D.1, Seungjun Lee, M.D.2, Sunjoo Kim , M.D.2, Oh-Hyun Cho, M.D.3, Hyunwoong Park, M.D.4, and Seong-Mi Yu, Ph.D.5
Departments of 1Emergency Medicine, 2Laboratory Medicine, and 3Internal Medicine, Institute of Health Sciences, Gyeongsang National University College of Medicine and Gyeongsang National University Changwon Hospital, Changwon, Korea; 4Department of Laboratory Medicine, Seoul National University Boramae Medical Center, Seoul, Korea; 5Division of Nursing, Gwangju Health University, Gwangju, Korea
Corresponding author: Sunjoo Kim, M.D. https://orcid.org/0000-0001-8099-8891
Department of Laboratory Medicine, Gyeongsang National University Changwon Hospital, 11 Samjungja-ro, Changwon 51472, Korea
Tel: +82-55-214-3072
Fax: +82-55-214-3087
E-mail: sjkim8239@hanmail.net
Received: July 17, 2018; Revised: October 2, 2018; Accepted: December 16, 2018; Published online: May 1, 2019.
© Korean Society for Laboratory Medicine. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: BacT/Alert Virtuo (BioMérieux, Durham, NC, USA) is a recently developed blood culture system that includes functions of automatic registration, loading, and unloading of the blood culture bottles, as well as measurement of blood volume. We compared the performances between the BacT/Alert Virtuo and 3D (BioMérieux) blood culture systems.
Methods: A total of 952 patients (1,904 sets) visiting an university-affiliated hospital in Korea for blood cultures were enrolled. Five milliliters of blood was added into each of the two aerobic (FA Plus) and two anaerobic (FN Plus) bottles of the Virtuo and 3D systems for a single set. Positive rate and time to detection (TTD) were compared between the two systems.
Results: The positive rates were 8.3% and 8.4% in FA Plus bottles and 7.8% and 8.3% in FN Plus bottles, in the Virtuo and 3D systems, respectively (P>0.05). Median TTDs were shorter in the Virtuo than in the 3D system for all isolates (11.5 hours [N=305] vs 11.8 hours [N=318], P<0.001), Staphylococcus aureus (N=38; 14.3 hours vs 16.0 hours, P=0.021), and Escherichia coli (N=117; 10.4 hours vs 11.0 hours, P<0.001).
Conclusions: The Virtuo has the potential to detect pathogens early in all bottle types. This might improve the prognosis of sepsis by allowing for implementation of expeditious management.
Keywords: BacT/Alert Virtuo, Blood cultures, Performance, Detection, Positive rate, Time to detection



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