30(03) 239-243
| A Rare Case of Acute Lymphoblastic Leukemia with t(12;17)(p13;q21) |
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| Ji-Eun Kim, M.D.11, Kwang-Sook Woo, M.D.1, Kyung-Eun Kim, M.D.1, Sung-Hyun Kim, M.D.2,
Joo-In Park, M.D.3, Lisa G. Shaffer, Ph.D.4, and Jin-Yeong Han, M.D.1,3 | | Departments of Laboratory Medicine1 and Internal Medicine2, Dong-A University College of Medicine, Busan; Medical Research Center
for Cancer Molecular Therapy3, Dong-A University, Busan, Korea; Signature Genomic Laboratories4, Spokane, WA, USA | |
| Patients with ALL rarely present with t(12;17)(p13;q21) as the primary clonal abnormality; this
abnormality is associated with the expression of myeloid antigens. In this study, we have reported
presumably the first case of this chromosomal abnormality in Korea, thereby facilitating the delineation
of a distinct subtype of ALL. A 57-yr-old woman was referred to our hospital because of pancytopenia.
Peripheral blood examination showed 55% blasts. The bone marrow was markedly
hypercellular, and about 82.4% of all nucleated cells were blasts. The results of immunophenotyping
and cytochemical staining suggested early precursor B-ALL. Cytogenetic analysis of the bone
marrow cells showed a complex karyotype, including a reciprocal translocation between the short
arm of chromosome 12 and the long arm of chromosome 17, t(12;17)(p13;q21). Data from array
comparative genomic hybridization were almost consistent with the cytogenetic findings. (Korean J
Lab Med 2010;30:239-43) |
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Korean J Lab Med 2010 Jun; 30(03) 239-243  |
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| DOI No. : 10.3343/kjlm.2010.30.3.239 |
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| Keyword : ALL, Balanced translocation, Microarray |
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