|Therapy-Related Myeloid Neoplasms in 39 Korean
Patients: A Single Institution Experience
|Hee Jae Huh, M.D.1, Soo Hyun Lee, M.D.2, Keon Hee Yoo, M.D.2, Ki Woong Sung, M.D.2, Hong Hoe Koo, M.D.2, Kihyun Kim, M.D.3, Jun-Ho Jang, M.D.3, Chulwon Jung, M.D.3, Sun-Hee Kim, M.D.1, and Hee-Jin Kim, M.D.1|
|Departments of Laboratory Medicine & Genetics1, Pediatrics2, and Medicine3, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea|
|Background: Therapy-related myeloid neoplasms (t-MN) occur as late complications of
cytotoxic therapy. This study reviewed clinical and cytogenetic characteristics of patients
with t-MN at a single institution in Korea.
Methods: The study subjects included 39 consecutive patients diagnosed with t-MN.
Each subject’s clinical history of previous diseases, treatments, and laboratory data was
reviewed, including cytogenetics. The primary diagnosis was hematologic malignancy in
14 patients and solid tumor in 25 patients.
Results: Therapy-related acute myeloid leukemia (t-AML, 66.7%) was found to be more
common than therapy-related myelodysplastic syndrome (t-MDS). Primary hematologic
malignancies that were commonly implicated included mature B-cell neoplasm and acute
leukemia. Breast cancer was the most common primary solid tumor. The mean time interval
from cytotoxic therapy initiation to t-MN detection was 49 months. Chromosomal aberrations
were observed in 35 patients, and loss of chromosome 5, 7, or both accounted for
41% of all cases. Balanced rearrangements occurred in 13 patients; these patients showed
shorter latency intervals (mean, 38 months) than patients with loss of chromosome 5 or 7
(mean, 61 months).
Conclusions: In this study, we determined the clinical and cytogenetic characteristics of
Korean patients with t-MN. Although our results were generally consistent with those of
previous reports, we found that t-MN resulting from de novo leukemia was common and
that t-AML was more common than t-MDS at presentation. Multi-institutional studies involving
a larger number of patients and additional parameters are required to investigate
the epidemiology, genetic predisposition, and survival rate of t-MN in Korea.|
Ann Lab Med 2013 Mar; 33(02) 97-104
| Keyword : Therapy-related neoplasms, Myelodysplastic syndrome, Acute myeloid leukemia,