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Cited by CrossRef (58)

  1. Xuemei Yang, Ning Dong, Edward Wai-Chi Chan, Rong Zhang, Sheng Chen. Carbapenem Resistance-Encoding and Virulence-Encoding Conjugative Plasmids in Klebsiella pneumoniae. Trends in Microbiology 2021;29:65
    https://doi.org/10.1016/j.tim.2020.04.012
  2. Jiankang Zhao, Chao Liu, Yingmei Liu, Yulin Zhang, Zhujia Xiong, Yanyan Fan, Xiaohui Zou, Binghuai Lu, Bin Cao. Genomic characteristics of clinically important ST11 Klebsiella pneumoniae strains worldwide. Journal of Global Antimicrobial Resistance 2020;22:519
    https://doi.org/10.1016/j.jgar.2020.03.023
  3. Zhou Liu, Xiubing Hang, Xiao Xiao, Wenwen Chu, Xin Li, Yangyang Liu, Xi Li, Qiang Zhou, Jiabin Li. Co-occurrence of blaNDM–1 and mcr-9 in a Conjugative IncHI2/HI2A Plasmid From a Bloodstream Infection-Causing Carbapenem-Resistant Klebsiella pneumoniae. Front. Microbiol. 2021;12
    https://doi.org/10.3389/fmicb.2021.756201
  4. Miklos Fuzi, Jesus Rodriguez Baño, Akos Toth. Global Evolution of Pathogenic Bacteria With Extensive Use of Fluoroquinolone Agents. Front. Microbiol. 2020;11
    https://doi.org/10.3389/fmicb.2020.00271
  5. Yi-Lin Hu, Shui-Lian Bi, Zang-Yun Zhang, Nian-Qing Kong. Correlation between Antibiotics-Resistance, Virulence Genes and Genotypes among Klebsiella pneumoniae Clinical Strains Isolated in Guangzhou, China. Curr Microbiol 2024;81
    https://doi.org/10.1007/s00284-024-03818-2
  6. Muhammad Usman Qamar, Bruno S Lopes, Brekhna Hassan, Mohsin Khurshid, Muhammad Shafique, Muhammad Atif Nisar, Mashkoor Mohsin, Zeeshan Nawaz, Saima Muzammil, Bilal Aslam, Hasan Ejaz, Mark A Toleman. The Present Danger of New Delhi Metallo-β-Lactamase: A Threat to Public Health. Future Microbiol. 2020;15:1759
    https://doi.org/10.2217/fmb-2020-0069
  7. Mohammad Hossein Haddadi, Saeed Khoshnood, Maryam Koupaei, Mohsen Heidary, Melika Moradi, Ali Jamshidi, Hamid Behrouj, Ahmad Movahedpour, Mohammad Hassan Maleki, Roya Ghanavati. Evaluating the incidence of ampC-β-lactamase genes, biofilm formation, and antibiotic resistance among hypervirulent and classical Klebsiella pneumoniae strains. 2023;134
    https://doi.org/10.1093/jambio/lxad241
  8. Lingyi Zeng, Jisheng Zhang, Chunjiang Li, Yanjun Fu, Yongxin Zhao, Yong Wang, Jing Zhao, Yuhang Guo, Xiaoli Zhang. The determination of gyrA and parC mutations and the prevalence of plasmid-mediated quinolone resistance genes in carbapenem resistant Klebsiella pneumonia ST11 and ST76 strains isolated from patients in Heilongjiang Province, China. Infection, Genetics and Evolution 2020;82:104319
    https://doi.org/10.1016/j.meegid.2020.104319
  9. Zhou Liu, Wenwen Chu, Xin Li, Wei Tang, Jun Ye, Qiang Zhou, Shihe Guan. Genomic Features and Virulence Characteristics of a Community-Acquired Bloodstream Infection-Causing Hypervirulent Klebsiella pneumoniae ST86 Strain Harboring KPC-2-Encoding IncX6 Plasmid. Microbial Drug Resistance 2021;27:360
    https://doi.org/10.1089/mdr.2019.0394
  10. Qi Li, Jiaying Zhu, Jianbang Kang, Yan Song, Donghong Yin, Qian Guo, Junli Song, Yan Zhang, Shuyun Wang, Jinju Duan.

    Emergence of NDM-5-Producing Carbapenem-Resistant Klebsiella pneumoniae and SIM-Producing Hypervirulent Klebsiella pneumoniae Isolated from Aseptic Body Fluid in a Large Tertiary Hospital, 2017–2018: Genetic Traits of blaNDM-Like and blaSIM-Like Genes as Determined by NGS

    . IDR 2020;Volume 13:3075
    https://doi.org/10.2147/IDR.S261117
  11. Emad M. Salawati. Fatal disseminated pyogenic infection due to hypermucoviscous hypervirulent Klebsiella pneumoniae: A case report and literature review. Clinical Case Reports 2021;9
    https://doi.org/10.1002/ccr3.4754
  12. Hiroki Namikawa, Ken-Ichi Oinuma, Koichi Yamada, Yukihiro Kaneko, Hiroshi Kakeya, Taichi Shuto. Differences in severity of bacteraemia caused by hypermucoviscous and non-hypermucoviscous Klebsiella pneumoniae. International Journal of Antimicrobial Agents 2023;61:106767
    https://doi.org/10.1016/j.ijantimicag.2023.106767
  13. Cong Su, Ting Wu, Bao Meng, Chengcheng Yue, Yating Sun, Lingling He, Tingting Bian, Yanyan Liu, Ying Huang, Yanhu Lan, Jiabin Li. High Prevalence of Klebsiella pneumoniae Infections in AnHui Province: Clinical Characteristic and Antimicrobial Resistance. IDR 2021;Volume 14:5069
    https://doi.org/10.2147/IDR.S336451
  14. Qiaoyan Duan, Qi Wang, Shijun Sun, Qiaozhen Cui, Qi Ding, Ruobing Wang, Hui Wang. ST11 Carbapenem-Resistant Klebsiella pneumoniae Clone Harboring blaNDM Replaced a blaKPC Clone in a Tertiary Hospital in China. Antibiotics 2022;11:1373
    https://doi.org/10.3390/antibiotics11101373
  15. Frederick Ofosu-Appiah, Ezra E. Acquah, Jibril Mohammed, Comfort Sakyi Addo, Bright Agbodzi, Dorcas A. S. Ofosu, Charles J. Myers, Quaneeta Mohktar, Opoku-Ware Ampomah, Anthony Ablordey, Nana Ama Amissah, Xiaohui Zhou. Klebsiella pneumoniae ST147 harboring bla NDM-1 , multidrug resistance and hypervirulence plasmids . Microbiol Spectr 2024;12
    https://doi.org/10.1128/spectrum.03017-23
  16. Mao Zhou, You Lan, Siyi Wang, Qingxia Liu, Zijuan Jian, Yanming Li, Xia Chen, Qun Yan, Wenen Liu. Epidemiology and molecular characteristics of the type VI secretion system in Klebsiella pneumoniae isolated from bloodstream infections. Clinical Laboratory Analysis 2020;34
    https://doi.org/10.1002/jcla.23459
  17. Heggadadevanakote Kendaganna Pavan, Bhargav Shreevatsa, Chandan Dharmashekara, Govindaraju Shruthi, Kollur Shiva Prasad, Sharanagouda S Patil, Chandan Shivamallu. Review of Known and Unknown Facts of Klebsiella Pneumoniae and its Relationship with Antibiotics. Biomed. Pharmacol. J. 2022;15:643
    https://doi.org/10.13005/bpj/2403
  18. Thomas A. Russo, Candace M. Marr. Hypervirulent Klebsiella pneumoniae. Clin Microbiol Rev 2019;32
    https://doi.org/10.1128/CMR.00001-19
  19. Enea Gino Di Domenico, Ilaria Cavallo, Francesca Sivori, Francesco Marchesi, Grazia Prignano, Fulvia Pimpinelli, Isabella Sperduti, Lorella Pelagalli, Fabiola Di Salvo, Ilaria Celesti, Silvia Paluzzi, Carmelina Pronesti, Tatiana Koudriavtseva, Fiorentina Ascenzioni, Luigi Toma, Assunta De Luca, Andrea Mengarelli, Fabrizio Ensoli. Biofilm Production by Carbapenem-Resistant Klebsiella pneumoniae Significantly Increases the Risk of Death in Oncological Patients. Front. Cell. Infect. Microbiol. 2020;10
    https://doi.org/10.3389/fcimb.2020.561741
  20. Christiana Jesumirhewe, Adriana Cabal-Rosel, Franz Allerberger, Burkhard Springer, Werner Ruppitsch. Genetic characterization of Escherichia coli and Klebsiella spp. from humans and poultry in Nigeria. 2023;5
    https://doi.org/10.1099/acmi.0.000509.v4
  21. Peng Lan, Yan Jiang, Jiancang Zhou, Yunsong Yu. A global perspective on the convergence of hypervirulence and carbapenem resistance in Klebsiella pneumoniae. Journal of Global Antimicrobial Resistance 2021;25:26
    https://doi.org/10.1016/j.jgar.2021.02.020
  22. Gina Maki, Marcus Zervos. Health Care–Acquired Infections in Low- and Middle-Income Countries and the Role of Infection Prevention and Control. Infectious Disease Clinics of North America 2021;35:827
    https://doi.org/10.1016/j.idc.2021.04.014
  23. Yu-Ling Han, Xu-Hui Wen, Wen Zhao, Xi-Shan Cao, Jian-Xun Wen, Jun-Rui Wang, Zhi-De Hu, Wen-Qi Zheng. Epidemiological characteristics and molecular evolution mechanisms of carbapenem-resistant hypervirulent Klebsiella pneumoniae. Front. Microbiol. 2022;13
    https://doi.org/10.3389/fmicb.2022.1003783
  24. Zhou Liu, Xiubing Hang, Tao Yan, Wenwen Chu, Zhen Gong, Yanyan Liu, Yuanyuan Dai, Min Yang, Jiabin Li, Qiang Zhou. A Simple Disk Stacking Plus Micro-Elution Method for Rapid Detection of the Synergistic Effect of Aztreonam and Ceftazidime/Avibactam Against Metallo-β-Lactamase Producing Enterobacterales. IDR 2023;Volume 16:1537
    https://doi.org/10.2147/IDR.S402275
  25. K. Luo, J. Tang, Y. Qu, X. Yang, L. Zhang, Z. Chen, L. Kuang, M. Su, D. Mu. Nosocomial infection by Klebsiella pneumoniae among neonates: a molecular epidemiological study. Journal of Hospital Infection 2021;108:174
    https://doi.org/10.1016/j.jhin.2020.11.028
  26. Guixiang Tao, Hua Tan, Jingjing Ma, Qian Chen. Resistance Phenotype and Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae Isolated from Nanjing Children’s Hospital in Jiangsu Province, China. IDR 2022;Volume 15:5435
    https://doi.org/10.2147/IDR.S377068
  27. Miran Tang, Xin Kong, Jingchen Hao, Jinbo Liu. Epidemiological Characteristics and Formation Mechanisms of Multidrug-Resistant Hypervirulent Klebsiella pneumoniae. Front. Microbiol. 2020;11
    https://doi.org/10.3389/fmicb.2020.581543
  28. J. E. Choby, J. Howard‐Anderson, D. S. Weiss. Hypervirulent Klebsiella pneumoniae – clinical and molecular perspectives. J Intern Med 2020;287:283
    https://doi.org/10.1111/joim.13007
  29. Qiang Zhao, Ling Guo, Li‐Feng Wang, Qian Zhao, Ding‐Xia Shen. Prevalence and characteristics of surgical site hypervirulent Klebsiella pneumoniae isolates. Clinical Laboratory Analysis 2020;34
    https://doi.org/10.1002/jcla.23364
  30. Ruifei Chen, Ziyi Liu, Poshi Xu, Xinkun Qi, Shangshang Qin, Zhiqiang Wang, Ruichao Li. Deciphering the Epidemiological Characteristics and Molecular Features of blaKPC–2- or blaNDM–1-Positive Klebsiella pneumoniae Isolates in a Newly Established Hospital. Front. Microbiol. 2021;12
    https://doi.org/10.3389/fmicb.2021.741093
  31. Kenneth P. Smith, Matthew G. Dowgiallo, Lucius Chiaraviglio, Prakash Parvatkar, Chungsik Kim, Roman Manetsch, James E. Kirby. A Whole-Cell Screen for Adjunctive and Direct Antimicrobials Active against Carbapenem-Resistant Enterobacteriaceae. SLAS Discovery 2019;24:842
    https://doi.org/10.1177/2472555219859592
  32. Yannan Liu, Sharon Shui Yee Leung, Yong Huang, Yatao Guo, Ning Jiang, Puyuan Li, Jichao Chen, Rentao Wang, Changqing Bai, Zhiqiang Mi, Zhancheng Gao. Identification of Two Depolymerases From Phage IME205 and Their Antivirulent Functions on K47 Capsule of Klebsiella pneumoniae. Front. Microbiol. 2020;11
    https://doi.org/10.3389/fmicb.2020.00218
  33. Likhona Dingiswayo, Olusesan Adeyemi Adelabu, Emmanuel Arko-Cobbah, Carolina Pohl, Nthabiseng Zelda Mokoena, Morne Du Plessis, Jolly Musoke. Hypervirulent Klebsiella pneumoniae in a South African tertiary hospital—Clinical profile, genetic determinants, and virulence in Caenorhabditis elegans. Front. Microbiol. 2024;15
    https://doi.org/10.3389/fmicb.2024.1385724
  34. Zongwei Zhang, Hainan Wen, Hui Wang, Pan Zhang, Jing Li, Yueyi Liang, Yanchao Liu, Lihong Sun, Shoujun Xie. A Case of Meningitis in an Infant Due to Hypervirulent Klebsiella pneumoniae Transmission Within a Family. IDR 2022;Volume 15:4927
    https://doi.org/10.2147/IDR.S376055
  35. Jaehyeon Lee, Jeong-Hwan Hwang, Ji Hyun Yeom, Sik Lee, Joo-Hee Hwang. Analysis of virulence profiles in clinical isolates of Klebsiella pneumoniae from renal abscesses: clinical significance of hypervirulent isolates. Front. Cell. Infect. Microbiol. 2024;14
    https://doi.org/10.3389/fcimb.2024.1367111
  36. Yajie Zhao, Xiucai Zhang, Von Vergel L. Torres, Haiyang Liu, Andrea Rocker, Yizhi Zhang, Jiawei Wang, Lijiang Chen, Wenzi Bi, Jie Lin, Richard A. Strugnell, Siqin Zhang, Trevor Lithgow, Tieli Zhou, Jianming Cao. An Outbreak of Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae in an Intensive Care Unit of a Major Teaching Hospital in Wenzhou, China. Front. Public Health 2019;7
    https://doi.org/10.3389/fpubh.2019.00229
  37. Cheng-Yen Kao, Yen-Zhen Zhang, Carl Jay Ballena Bregente, Pei-Yun Kuo, Pek Kee Chen, Jo-Yen Chao, Tran Thi Thuy Duong, Ming-Cheng Wang, Tran Thi Dieu Thuy, Jazon Harl Hidrosollo, Pei-Fang Tsai, Ying-Chi Li, Wei-Hung Lin. A 24-year longitudinal study of Klebsiella pneumoniae isolated from patients with bacteraemia and urinary tract infections reveals the association between capsular serotypes, antibiotic resistance, and virulence gene distribution. Epidemiol. Infect. 2023;151
    https://doi.org/10.1017/S0950268823001486
  38. Xinhong Han, Jiayao Yao, Jintao He, Haiyang Liu, Yan Jiang, Dongdong Zhao, Qiucheng Shi, Junxin Zhou, Huangdu Hu, Peng Lan, Hua Zhou, Xi Li. Clinical and laboratory insights into the threat of hypervirulent Klebsiella pneumoniae. International Journal of Antimicrobial Agents 2024;64:107275
    https://doi.org/10.1016/j.ijantimicag.2024.107275
  39. Can Wang, Qiang Wang, Zhiqiang Mi, Lei Zhao, Changqing Bai. Genomic analysis of K47-type Klebsiella pneumoniae phage IME305, a newly isolated member of the genus Teetrevirus. Arch Virol 2023;168
    https://doi.org/10.1007/s00705-023-05900-9
  40. Mengli Tang, Jun Li, Zhaojun Liu, Fengjun Xia, Changhang Min, Yongmei Hu, Haichen Wang, Mingxiang Zou. Clonal transmission of polymyxin B-resistant hypervirulent Klebsiella pneumoniae isolates coharboring blaNDM-1 and blaKPC-2 in a tertiary hospital in China. BMC Microbiol 2023;23
    https://doi.org/10.1186/s12866-023-02808-x
  41. Joo-Hee Hwang, Jeong-Hwan Hwang, Seung Yeob Lee, Jaehyeon Lee. Prostatic Abscess Caused by Klebsiella pneumoniae: A 6-Year Single-Center Study. JCM 2022;11:2521
    https://doi.org/10.3390/jcm11092521
  42. Clement Yaw Effah, Tongwen Sun, Shaohua Liu, Yongjun Wu. Klebsiella pneumoniae: an increasing threat to public health. Ann Clin Microbiol Antimicrob 2020;19
    https://doi.org/10.1186/s12941-019-0343-8
  43. Wenjian Liao, Yang Liu, Wei Zhang. Virulence evolution, molecular mechanisms of resistance and prevalence of ST11 carbapenem-resistant Klebsiella pneumoniae in China: A review over the last 10 years. Journal of Global Antimicrobial Resistance 2020;23:174
    https://doi.org/10.1016/j.jgar.2020.09.004
  44. Chang-Hun Lee, Jeong Don Chae, Wonho Choe, Hyo Young Lee, Yong-Hak Sohn, Chunhwa Ihm, Ji Hun Jeong. Osteomyelitis Caused by Hypervirulent Klebsiella pneumoniae: The First Korean Case With Family Spread. Ann Lab Med 2021;41:250
    https://doi.org/10.3343/alm.2021.41.2.250
  45. Piaopiao Dai, Dakang Hu. The making of hypervirulent Klebsiella pneumoniae. Clinical Laboratory Analysis 2022;36
    https://doi.org/10.1002/jcla.24743
  46. Wanni Cai, Jianbang Kang, Yanbin Ma, Donghong Yin, Yan Song, Yujie Liu, Jinju Duan. Molecular Epidemiology of Carbapenem Resistant Klebsiella Pneumoniae in Northern China: Clinical Characteristics, Antimicrobial Resistance, Virulence and Geographic Distribution. IDR 2023;Volume 16:7289
    https://doi.org/10.2147/IDR.S436284
  47. Miri Hyun, Ji Yeon Lee, Hyun Ah Kim. Clinical and Microbiologic Analysis of Klebsiella pneumoniae Infection: Hypermucoviscosity, Virulence Factor, Genotype, and Antimicrobial Susceptibility. Diagnostics 2024;14:792
    https://doi.org/10.3390/diagnostics14080792
  48. Xiangyun Wu, Jiayi Liu, Jiawei Feng, Muhammad Abu Bakr Shabbir, Yali Feng, Rui Guo, Meifang Zhou, Sulin Hou, Guiqiang Wang, Haihong Hao, Guyue Cheng, Yulian Wang. Epidemiology, Environmental Risks, Virulence, and Resistance Determinants of Klebsiella pneumoniae From Dairy Cows in Hubei, China. Front. Microbiol. 2022;13
    https://doi.org/10.3389/fmicb.2022.858799
  49. Mohamed Abd El-Gawad El-Sayed Ahmed, Yanxian Yang, Yongqiang Yang, Bin Yan, Guanping Chen, Reem Mostafa Hassan, Lan-Lan Zhong, Yuan Chen, Adam P. Roberts, Yiping Wu, Ruowen He, Xiaoxue Liang, Mingyang Qin, Min Dai, Liyan Zhang, Hongyu Li, Fan Yang, Lingqing Xu, Guo-Bao Tian, Patricia A. Bradford. Emergence of Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Coharboring a bla NDM-1 -Carrying Virulent Plasmid and a bla KPC-2 -Carrying Plasmid in an Egyptian Hospital . mSphere 2021;6
    https://doi.org/10.1128/mSphere.00088-21
  50. Bao-Tao Liu, Wei-Qi Su. Whole genome sequencing of NDM-1-producing serotype K1 ST23 hypervirulent Klebsiella pneumoniae in China. 2019;68:866
    https://doi.org/10.1099/jmm.0.000996
  51. Amina Javid, Mehboob Ahmed. A computational odyssey: uncovering classical β-lactamase inhibitors in dry fruits. Journal of Biomolecular Structure and Dynamics 2024;42:4578
    https://doi.org/10.1080/07391102.2023.2220817
  52. Jie Feng, Qian Xiang, Jiangang Ma, Pei Zhang, Kun Li, Ke Wu, Mengru Su, Ruichao Li, Daniel Hurley, Li Bai, Juan Wang, Zengqi Yang. Characterization of Carbapenem-Resistant Enterobacteriaceae Cultured From Retail Meat Products, Patients, and Porcine Excrement in China. Front. Microbiol. 2021;12
    https://doi.org/10.3389/fmicb.2021.743468
  53. Sara Davoudabadi, Hossein Goudarzi, Mehdi Goudarzi, Abdollah Ardebili, Ebrahim Faghihloo, Javad Yasbolaghi Sharahi, Ali Hashemi. Detection of extensively drug-resistant and hypervirulent Klebsiella pneumoniae ST15, ST147, ST377 and ST442 in Iran. AMicr 2022;69:77
    https://doi.org/10.1556/030.2021.01562
  54. Xinchun Wang, Qi Li, Jianbang Kang, Donghong Yin, Xiaoxia Li, Shuyun Wang, Qian Guo, Yan Song, Jing Wang, Jinju Duan. Mortality Risk Factors and Prognostic Analysis of Patients with Multi-Drug Resistant Enterobacterales Infection. IDR 2022;Volume 15:3225
    https://doi.org/10.2147/IDR.S366808
  55. Tao Chen, Yuan Wang, Yanzi Zhou, Wangxiao Zhou, Xiaohui Chi, Ping Shen, Beiwen Zheng, Yonghong Xiao, Chi-Tai Fang. Recombination Drives Evolution of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 KL47 to KL64 in China. Microbiol Spectr 2023;11
    https://doi.org/10.1128/spectrum.01107-22
  56. Xiaolang Tian, Changwu Huang, Xiaoli Ye, Hongyan Jiang, Rufang Zhang, Xiaofang Hu, Dongshuang Xu. Molecular Epidemiology of and Risk Factors for Extensively Drug-Resistant Klebsiella pneumoniae Infections in Southwestern China: A Retrospective Study. Front. Pharmacol. 2019;10
    https://doi.org/10.3389/fphar.2019.01307
  57. Masoumeh Beig, Shadi Aghamohammad, Nahal Majidzadeh, Mahshid Khazani Asforooshani, Niloofar Rezaie, Sahar Abed, Elham Hajagha Gholizadeh Khiavi, Mohammad Sholeh. Antibiotic resistance rates in hypervirulent Klebsiella pneumoniae strains: A systematic review and meta-analysis. Journal of Global Antimicrobial Resistance 2024;38:376
    https://doi.org/10.1016/j.jgar.2024.06.018
  58. Adriano de Souza Santos Monteiro, Soraia Machado Cordeiro, Joice Neves Reis. Virulence Factors in Klebsiella pneumoniae: A Literature Review. Indian J Microbiol 2024;64:389
    https://doi.org/10.1007/s12088-024-01247-0