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  • Review Article2024-09-01 General Laboratory Medicine

    Next-Generation Patient-Based Real-Time Quality Control Models

    Xincen Duan , Ph.D., Minglong Zhang , M.Sc., Yan Liu , Ph.D., Wenbo Zheng , Ph.D., Chun Yee Lim , Ph.D., Sollip Kim , Ph.D., Tze Ping Loh , M.B., BCh, BAO, Wei Guo , Ph.D., Rui Zhou , M.D., Ph.D., and Tony Badrick , Ph.D.; On behalf of the Patient-Based Real-Time Quality Control Working Group of the Asia Pacific Federation of Clinical Biochemistry and Laboratory Medicine

    Ann Lab Med 2024; 44(5): 385-391

    Abstract : Patient-based real-time QC (PBRTQC) uses patient-derived data to assess assay performance. PBRTQC algorithms have advanced in parallel with developments in computer science and the increased availability of more powerful computers. The uptake of Artificial Intelligence in PBRTQC has been rapid, with many stated advantages over conventional approaches. However, until this review, there has been no critical comparison of these. The PBRTQC algorithms based on moving averages, regression-adjusted real-time QC, neural networks and anomaly detection are described and contrasted. As Artificial Intelligence tools become more available to laboratories, user-friendly and computationally efficient, the major disadvantages, such as complexity and the need for high computing resources, are reduced and become attractive to implement in PBRTQC applications.

  • Original Article2023-09-01 General Laboratory Medicine

    Status of Pre-analytical Quality Management of Laboratory Tests at Primary Clinics in Korea

    Jeonghyun Chang , Ph.D., Jinsook Lim , Ph.D., Jae-Woo Chung , Ph.D., Yong-Hak Sohn , Ph.D., Min Joong Jang , M.D., and Sollip Kim , Ph.D.

    Ann Lab Med 2023; 43(5): 493-502

    Abstract : Background: The quality of laboratory test results is crucial for accurate clinical diagnosis and treatment. Pre-analytical errors account for approximately 60%–70% of all laboratory test errors. Laboratory test results may be largely impacted by pre-analytical phase management. However, primary care clinics currently do not have pre-analytical quality management audit systems. We aimed to understand the current status of pre-analytical quality management in laboratory medicine in Korean primary care clinics. Methods: Questionnaires were designed to focus on essential components of the pre-analytical process of primary care clinics. An online survey platform was used to administer the survey to internal medicine or family medicine physicians in primary care clinics. Results: A total of 141 physicians provided a complete response to the questionnaire. In 65.2% of the clinics, patient information was hand-labeled rather than barcoded on the specimen bottles; 14.2% of clinics displayed only one piece of patient information (name or identification number), and 19.9% of clinics displayed two pieces of information. Centrifuges were not available in 29.1% of the clinics. Institutions carrying out the National Health Screening Program (NHSP) used more barcode system and had more centrifuges than institutions that did not carrying out the NHSP. Conclusions: Pre-analytical quality management is inadequate in many primary clinics. We suggest implementation of a mandatory management system, allowing for a pre-analytical quality management to be carried out in primary care clinics.

  • Guideline2024-03-01 General Laboratory Medicine

    The LEAP Checklist for Laboratory Evaluation and Analytical Performance Characteristics Reporting of Clinical Measurement Procedures

    Tze Ping Loh , M.B., B.Ch., B.A.O., Brian R Cooke , Ph.D., Thi Chi Mai Tran , Ph.D., Corey Markus , B.Sc., Rosita Zakaria , Ph.D., Chung Shun Ho , Ph.D., Elvar Theodorsson , Ph.D., and Ronda F Greaves , Ph.D.; on behalf of the IFCC Working Group on Method Evaluation Protocols (WG-MEP)

    Ann Lab Med 2024; 44(2): 122-125

    Abstract : Reporting a measurement procedure and its analytical performance following method evaluation in a peer-reviewed journal is an important means for clinical laboratory practitioners to share their findings. It also represents an important source of evidence base to help others make informed decisions about their practice. At present, there are significant variations in the information reported in laboratory medicine journal publications describing the analytical performance of measurement procedures. These variations also challenge authors, readers, reviewers, and editors in deciding the quality of a submitted manuscript. The International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Method Evaluation Protocols (IFCC WG-MEP) developed a checklist and recommends its adoption to enable a consistent approach to reporting method evaluation and analytical performance characteristics of measurement procedures in laboratory medicine journals. It is envisioned that the Laboratory Evaluation and Analytical Performance Characteristics (LEAP) checklist will improve the standardisation of journal publications describing method evaluation and analytical performance characteristics, improving the quality of the evidence base that is relied upon by practitioners.

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Annals of Laboratory Medicine
Journal Information November, 2024
Vol.44 No.6
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