OPEN ACCESS pISSN 2234-3806
eISSN 2234-3814

Table. 3.

Table. 3.

Correlations between clinical characteristics and HCC driver gene pathogenic variants detected in cfDNA

Patients with variants in cfDNA (%) Patients without variants in cfDNA (%) P Patients with TP53 variants in cfDNA (%) Patients without TP53 variants in cfDNA (%) P Patients with CTNNB1 variants in cfDNA (%) Patients without CTNNB1 variants in cfDNA (%) P
Sex Male (N = 17) 65 35 1.00 53 47 1.00 29 71 0.27
Female (N = 3) 67 33 67 33 67 33
Macrovascular invasion Yes (N = 9) 56 44 0.64 44 6 0.65 33 67 1.00
No (N = 11) 73 27 64 36 36 64
Multiplicity Yes (N = 17) 59 41 0.52 47 53 0.22 29 71 0.27
No (N = 3) 100 0 100 0 67 33
Metastasis Yes (N = 14) 64 36 1.00 50 50 0.64 36 64 1.00
No (N = 6) 67 33 67 33 33 67
HBV Positive (N = 15) 67 33 1.00 53 47 1.00 33 67 1.00
Negative (N = 5) 60 40 60 40 40 60
HCV Positive (N = 3) 33 67 0.27 33 67 0.57 33 67 1.00
Negative (N = 17) 71 29 59 41 35 65
ALD Yes (N = 3) 67 33 1.00 67 33 1.00 33 67 1.00
No (N = 17) 65 35 53 47 35 65

Abbreviations: cfDNA, cell-free DNA; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; ALD, alcoholic liver disease.

Ann Lab Med 2021;41:198~206 https://doi.org/10.3343/alm.2021.41.2.198

© Ann Lab Med