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Table. 1.

Table. 1.

Overview of the proficiency test scheme of the Korean Association of External Quality Assessment Service

Discipline Classification of the Program Program Tests Distribution/yr Specimen (origin; type; state; preparation) Shipping conditions (°C) N participants (2020)
Transfusion medicine Pretransfusion testing Blood crossmatching and Blood typing, general Blood crossmatching; ABO typing; RhD typing 2 Human; WB; Liquid; IH FRG 923
Blood typing, special ABO subtyping; Rh CcEe Ag test; Weak D test 2 Human; WB; Liquid; IH FRG 253
Transfusion Ab, general Unexpected Ab, screening; Direct anti-human globulin test 2 Human; WB and plasma; Liquid; IH FRG 335
Transfusion Ab, special Unexpected Ab, identification; ABO Ab titration 2 Human; Plasma; Liquid; IH FRG 139
Diagnostic hematology Hematology and clinical microscopy CBC and microscopy CBC 2 Animal; WB; Liquid; P FRG 1,819
Blood cell morphology 2 Human; Blood smear; Image; IH
Peripheral blood smear (pilot project) Malaria detection; Parasitemia; Identification 2 Human; Blood smear; Image; IH 277
ESR (pilot project) ESR 2 Synthetic material; Latex; Liquid; P FRG 448
Human; WB; Liquid; P FRG
Coagulation Coagulation, general PT INR; aPTT; Coagulation factor I (fibrinogen); Thrombin time; Antithrombin III activity 2 Human; Plasma; Lyophilized; P FRG 606
Coagulation, special Protein C (functional); Protein S (functional) 2 Human; Plasma; Lyophilized; P FRG 20
Clinical chemistry Urinalysis and stool occult blood, etc. Urinalysis Urinalysis 3 Animal; Serum, Hb and Enzyme; Liquid; P FRG 1,726
Urine sediment 3 Human; Urine; Image; IH
Stool occult blood Stool occult blood (QL); Stool occult blood (QN) 2 Other origins; Hb; Lyophilized; P FRG 1,014
Blood gas analysis Blood gas analysis pH; pCO2; pO2; Lactic acid; Ionized calcium; Ionized magnesium; Sodium; Potassium; Chloride 2 DW; Buffered bicarbonate and electrolyte solution; Liquid; P FRG 420
Blood gas analysis, POCT pH; pCO2; pO2 2 DW; Buffered bicarbonate and electrolyte solution; Liquid; P FRG 177
General chemistry Routine chemistry Sodium; Potassium; Chloride; Calcium; Phosphorus; Magnesium; BUN; Glucose; Cholesterol; HDL-C; LDL-C; TG; ALT; ALP; AST; Bilirubin, total; Bilirubin, direct; Albumin; Protein; GGT; LDH; Amylase; Lipase; CK; Uric acid; Iron; TIBC; Total CO2; Osmolality 4 Human; Serum; Lyophilized; P FRG 1,801
ICG test ICG concentration; K; R15 2 Human; plasma; Liquid FRG 40
Urine chemistry Urine albumin; Calcium; Chloride; Creatinine; Glucose; Magnesium; Phosphorus; Potassium; Urine protein; Sodium; Urea Nitrogen; Uric acid; hCG 2 Human; Urine; Lyophilized; P FRG 304
Special proteins Special proteins Ceruloplasmin; Ferritin; Transferrin; Haptoglobin; Prealbumin; Alpha1-antitrypsin; CRP (QL); CRP (QN); ASO (QL); ASO (QN); RF (QL); RF (QN) 2 Human; Serum; Liquid; P F 620
Carbohydrates, lipids, proteins, and vitamins Glucose, POCT Glucose Human; Serum and Hb; Liquid; P FRG 375
Cardiac markers CK-MB, mass; CK-MB, activity; Homocysteine; Myoglobin; Troponin I; Troponin T; BNP; Pro-BNP; High sensitivity CRP 2 Human; Serum; Liquid; IH F 475
Metabolism testing Newborn screening Total galactose; 17-hydroxyprogesterone; TSH; T4, total; Newborn screening for inborn error of metabolism 2 Human; WB; Dried blood spot; IH F 17
Organic acid profile Organic acid profile 2 Human; Urine; Liquid; IH F 5
Amino acid profile Amino acid profile 2 Human; Plasma; Liquid; IH F 7
Special metabolites Methylmanonic acid; Vanillylmandelic acid; Epinephrine, urine; Norepinephrine, urine; Dopamine, urine; Metanephrine, urine; Normetanephrine, urine; Epinephrine, plasma; Norepinephrine, plasma; Dopamine, plasma; Metanephrine, plasma; Normetanephrine, plasma 2 Human; Urine and plasma; Liquid; IH F 10
Endocrinology Hormones I TSH; T4, total; T4, free; T3, total; Thyroglobulin; hCG, total (serum); Testosterone; Estradiol; Progesterone; Prolactin; Insulin; Folate; Human growth hormone; Vitamin B12; Cortisol 2 Human; Serum; Liquid; P F 661
Hormones II PTH; Erythropoietin; Vitamin D; Procalcitonin 2 Human; Serum; Lyophilized; P FRG 315
Hormones III (pilot project) Anti-Mullerian hormone 2 Human; Serum; Liquid F 31
Tumor markers Tumor markers I AFP (QN); CEA; PSA; PIVKA-II 2 Human; Serum; Liquid; IH F 723
Tumor markers II CA 125; CA 19-9; CA 15-3; CA 72-4; Beta2-microglobulin; Human epididymis protein 4 2 Human; Serum; Lyophilized; P FRG 446
Therapeutic drug monitoring and toxicology Therapeutic drug monitoring, general Acetaminophen; Amikacin; Amitriptyline; Carbamazepine; Carbamazepine,free; Chloramphenicol; Desipramine; Disopyramide; Digoxin; Ethosuximide; Lidocaine; Gentamicin; Lithium; Methotrexate; Nortriptyline; Phenobarbital; Phenytoin; Phenytoin, free; Primidone; Procainamide; Propranolol; Quinidine; Salicylate; Theophylline; Tobramycin; Valproic acid; Valproic acid, free; Vancomycin 2 Human; Serum; Lyophilized; P FRG 106
Immunosuppressants therapeutic drug monitoring Cyclosporine; Tacrolimus (FK506); Sirolimus; Everolimus 2 Human; WB; Liquid; P FRG 13
Therapeutic drug monitoring, special MPA; Voriconazole; Posaconazole; Itraconazole 2 Human; Serum; Liquid; IH FRG 77
Drug of abuse (QL) Amphetamine; Methamphetamine; MDMA; Morphine, Free; Phencyclidine; 3,4-Secobarbital; 9-COOH-11-nor-Δ9-THC; Benzoylecgonine; Ethanol; LSD; Methadone; Methaqualone; Nordiazepam; Nortriptyline; Oxazepam; Propoxyphene 2 Human; Urine; Liquid; P FRG 141
Accuracy-based chemistry Accuracy-based lipids Cholesterol, total; HDL-C; LDL-C; TG; Apolipoprotein A1; Apolipoprotein B; Lipoprotein(a) 2 Human; Serum; Liquid; IH F 275
Accuracy-based creatinine Creatinine; estimated GFR 2 Human; Plasma; Liquid; IH F 1,758
Accuracy-cased HbA1c HbA1c 2 Human; WB; Liquid; IH FRG 597
Diagnostic immunology Complements and immunoglobulins Complements and immunoglobulins C3; C4; IgG; IgA; IgM; IgE; FLC, kappa; FLC, lambda 2 Human; Serum; Liquid; P F 164
Serology Syphilis tests Non-treponemal test; Treponemal test 2 Human; Plasma; Liquid; IH F 595
Hepatitis serology HBsAg; HBsAb; HCV Ab; HBcAb, total; HBc Ab, IgM; HBeAg; HBeAb; HAV Ab, total; HAV Ab, IgG; HAV Ab, IgM 2 Human; Plasma; Liquid; IH F 1,103
Virus serology I HIV Ag/Ab; HTLV Ab; CMV Ab, IgG; CMV Ab, IgM 2 Human and Animal; Serum; Liquid; IH F 591
Virus serology II Rubella IgG; Rubella IgM; EBV Viral Capsid Ag, IgG; EBV Viral Capsid Ag, IgM; EBV Nucleic Acid Ag, IgG 2 Human and Animal; Serum; Liquid; IH F 93
Histocompatibility testing HLA typing HLA Typing 2 Human; WB; Liquid; IH FRG 69
HLA typing, special HLA B27 Typing; HLA B51 Typing 2 Human; WB; Liquid; IH FRG 62
HLA crossmatching HLA crossmatching, CDC; HLA crossmatching, flow cytometry 2 Human; Serum and PBMC; Liquid; IH RT (PBMC) and FRG (serum) 48
HLA Ab tests HLA Ab screening; HLA Ab identification 2 Human; Serum; Liquid; IH FRG 26
Cellular immunity, flow cytometry Lymphocyte subset assay Lymphocyte subset assay 2 Human; WB; Liquid; IH RT 56
Stem/progenitor cell assay CD34+Stem/Progenitor cell assay 2 Human; WB; Liquid; IH RT 42
Hematologic malignancy immunophenotyping Hematologic malignancy immunophenotyping 2 Human; WB and BM aspirate; Liquid; IH RT 44
Autoimmunity Autoimmune Assay I ANA; Anti-mitochondrial Ab; Anti-smooth muscle Ab 2 Human; Serum; Liquid; IH F 82
Autoimmune Assay II Anti-thyroglobulin Ab; Anti-thyroperoxidase Ab; Anti-dsDNA Ab 2 Human; Serum; Liquid; IH F 111
Allergy test Allergy test Allergen-specific IgE (QN), Multi-allergen screen (Semi-QN) 2 Human; Serum; Liquid; IH F 121
Infection-induced immune responses Tuberculosis Ag response IGRA 2 Animal; Serum and Interferon-gamma power; Lyophilized; IH FRG 76
Clinical microbiology Microbiology Mycobacteriology, general Acid-fast stain microscopy 3 Human; MTB; Slide; IH FRG 255
Acid fast bacilli culture; Acid fast bacilli identification 3 Human; Sputum; Liquid; IH FRG
Mycobacteriology, drug sensitivity Acid-fast bacilli antibiotic sensitivity 3 Human; MTB; Liquid; IH FRG 7
Bacteriology Bacteria stain microscopy; Bacteria culture; Bacteria identification; Antibiotics sensitivity test 3 Human; Bacteria; Liquid medium; IH FRG 282
Mycology Fungus stain microscopy; Fungus culture; Fungus identification 2 Human; Fungus; Liquid medium; IH FRG 135
Parasitology Parasite eggs image 3 Human and Animal; Parasite egg; Image; IH FRG 217
Parasite eggs slide 3 Human and Animal; Parasite egg; Slide; IH FRG
Molecular diagnostics Molecular microbiology Molecular microbiology, mycobacteria MTB DNA; MTB DNA, isoniazid resistance mutation; MTB DNA, rifampicin resistance mutation 3 Human; MTB and NTM; Liquid; IH FRG 132
Molecular microbiology, hepatitis viruses HBV (QL); HBV (QN); HCV (QL); HCV (QN); HBV DNA drug resistance mutation 2 Human; Plasma; Liquid; IH F 121
Molecular microbiology, viruses CMV (QL); CMV (QN); EBV (QL); EBV (QN); HPV (QL); HIV (QL); HIV (QN); Adenovirus (QL); Influenzavirus A,B (QL); Parainfluenza 1,2,3 virus (QL); RSV (QL), BK virus (QL) 2 Human; Serum (Plasma); Liquid; IH F 124
2 Human; Virus; Liquid; IH F
Human genetics Cytogenetics Chromosomal analysis 3 Human; WB; Image; IH - 40
FISH Fluorescence in situ hybridization 3 Human; WB; Slide; IH F 32
Molecular, hematologic malignancy Leukemia gene rearrangement; JAK2 gene V617F mutation; FLT3 gene internal tandem duplication; FLT3 gene tyrosine kinase domain mutation; NPM1 gene mutation, CALR gene mutation 2 Human; WB; Liquid (DNA); IH FRG 48
Molecular, solid tumors KRAS gene mutation; EGFR gene mutation; BRAF gene mutation; KIT (C-Kit) gene mutation 2 Human; DNA; Liquid; IH FRG 28
Molecular, genetic disorders BRCA1; BRCA2; TP53; ATP7B; MT-TL1; MT-TK; GJB2; LHON major mutation; RET; Spinocerebellar ataxia; APOE genotyping; FGFR3 major mutation; MTHFR genotyping; Prader-Willi/Angelman syndrome; DMD, Del/Dup; HD gene trinucleotide repeat expansion; FMR1 gene trinucleotide repeat expansion; TGFBI major mutation; SBMA; SMN1, Del/Dup 2 Human; DNA; Liquid; IH FRG 56
Pharmacogenetics, Molecular, pharmacogenetics CYP2C19 genotyping; CYP2C9 genotyping; VKORC1 genotyping; CYP2D6 genotyping; TPMT genotyping 2 Human; DNA; Liquid; IH FRG 21
Human genetics, others Molecular, others ABO genotyping 2 Human; DNA; Liquid; IH FRG 16
Liquid biopsy EGFR gene 2 Human; Plasma; Liquid; IH F 30
NGS, somatic NGS - somatic 2 Human; DNA; Liquid and FASTQ file; IH F 23
NGS, germline NGS - germline 2 Human; DNA; Liquid and FASTQ file; IH F 24
NGS, liquid biopsy (pilot project) NGS - liquid biopsy 2 Human; DNA; Liquid F 5

Abbreviations: Ab, antibody; AFP, alpha-fetoprotein; Ag, antigen; ALP, alkaline phosphatase; ALT, alanine transferase; ANA, anti-nuclear Ab; aPTT, activated partial thromboplastin time; ASO, anti-streptolysin O; AST, aspartate aminotransferase; BNP, brain natriuretic peptide; BUN, blood urea nitrogen; C, complement component; CA, cancer antigen; CBC, complete blood cell count; CDC, complement-dependent cytotoxicity; CEA, carcinoembryonic Ag; CK, creatine kinase; CK-MB, creatine kinase-MB; CMV, cytomegalovirus; CRP, C-reactive protein; EBV, Epstein-Barr virus; estimated GFR, estimated glomerular filtration rate; F, frozen; FISH, fluorescence in situ hybridization; FLC, free light chain; FRG, refrigerated; GGT, gamma-glutamyl transferase; HAV, hepatitis A virus; Hb, hemoglobin; HbA1c, hemoglobin A1c; HBcAb, hepatitis B virus core Ab; HBeAb hepatitis B virus envelope Ab; HBeAg, hepatitis B virus envelope Ag; HBsAb, hepatitis B virus surface Ab; HBsAg, hepatitis B virus surface Ag; hCG, human chorionic gonadotropin; HCV, hepatitis C virus; HDL-C, high-density lipoprotein cholesterol; HIV, human immunodeficiency virus; HLA, human leukocyte antigen; HPV, human papillomavirus; HTLV, human T-lymphotropic virus; ICG, indocyanine green; Ig, immunoglobulin; IGRA, interferon-gamma release assay; IH, in-house prepared quality material; LDH, lactate dehydrogenase; LDL-C, low-density lipoprotein cholesterol; LSD, lysergic acid diethylamide; MDMA, methylene dioxy methamphetamine; MPA, methiopropamine; NGS, next-generation sequencing; P, purchased quality material; PBMC, peripheral blood mononuclear cell; PIVKA-II, protein induced by vitamin K absence or antagonist-II; POCT, point-of-care testing; PSA, prostate-specific antigen; PT, prothrombin time; PTH, parathyroid hormone; QL, qualitative; QN, quantitative; RF, rheumatoid factor; RSV, respiratory syncytial virus; RT, room temperature; T3, triiodothyronine; T4, thyroxine; TG, triglyceride; TIBC, total iron-binding capacity; TSH, thyroid-stimulating hormone; WB, whole blood.

Ann Lab Med 2021;41:230~239 https://doi.org/10.3343/alm.2021.41.2.230

© Ann Lab Med