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Table. 3.

Table. 3.

Diagnostic efficacy of serum M2BPGi and other serum markers for different liver fibrosis stages

AUC (95% CI) Cut-off value Sensitivity (%) Specificity (%) P
M2BPGi
F>0 0.761 (0.648–0.875) 0.54 66.0 78.9 0.004
F>1 0.819 (0.743–0.895) 0.65 70.5 84.6 0.005
F>2 0.866 (0.791–0.940) 0.71 85.3 78.5 < 0.001
F>3 0.900 (0.829–0.972) 0.90 92.3 77.0 < 0.001
APRI
F>0 0.778 (0.676–0.880) 0.76 61.7 89.5 0.109
F>1 0.793 (0.708–0.877) 0.76 77.0 75.0 < 0.001
F>2 0.758 (0.661–0.855) 0.76 88.2 62.0 < 0.001
F>3 0.641 (0.497–0.786) 0.76 84.6 52.0 < 0.001
FIB-4
F>0 0.783 (0.694–0.871) 1.39 56.4 100.0 < 0.001
F>1 0.852 (0.781–0.922) 1.23 78.7 84.6 < 0.001
F>2 0.918 (0.857–0.980) 1.70 91.2 79.7 < 0.001
F>3 0.894 (0.801–0.986) 3.30 84.6 87.0 < 0.001
NFS
F>0 0.687 (0.586–0.788) -1.83 54.3 89.5 < 0.001
F>1 0.820 (0.743–0.898) -1.62 68.9 90.4 < 0.001
F>2 0.920 (0.862–0.977) -1.04 79.4 93.7 < 0.001
F>3 0.926 (0.841–1.000) 0.25 84.6 94.0 < 0.001

Abbreviations: AUC, area under the curve; APRI, aspartate aminotransferase to platelet ratio index; F, fibrosis; FIB-4, fibrosis index based on four factors; NAFLD, non-alcoholic fatty liver disease; NFS, NAFLD fibrosis score; M2BPGi, Mac-2 binding protein glycosylation isomer.

Ann Lab Med 2021;41:302~309 https://doi.org/10.3343/alm.2021.41.3.302

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