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Table. 4.

Table. 4.

Univariate and multivariate logistic regression analyses of variables associated with advanced fibrosis (F>2) and cirrhosis (F>3) and C-statistics

Variable Univariate C-statistics Model 1* C-statistics Model 2 C-statistics


Multivariate Multivariate



Odds ratio (95% CI) P Odds ratio (95% CI) P Odds ratio (95% CI) P
F>2 0.95 (0.90–0.99) 0.94 (0.90–0.98)
M2BPGi 9.572 (3.668–24.978) < 0.001 0.87 (0.80–0.93) 4.949 (1.424–17.196) 0.0125.187 (1.648–16.328) 0.005
APRI 3.500 (1.711–7.161) 0.001 0.76 (0.68–0.84) 0.658 (0.160–2.713) 0.563
FIB-4 4.043 (2.405–6.797) < 0.001 0.92 (0.87–0.97) 1.981 (0.677–5.795) 0.212
NFS 3.860 (2.291–6.502) < 0.001 0.92 (0.87–0.97) 2.089 (0.905–4.819) 0.0843.376 (1.941–5.870) < 0.001
F>3 0.95 (0.91–0.99) 0.94 (0.90–0.98)
M2BPGi 5.818 (2.368–14.297) < 0.001 0.90 (0.84–0.96) 3.605 (1.111–11.701) 0.0333.244 (1.126–9.345) 0.033
APRI 1.270 (0.681–2.370) 0.453 0.64 (0.55–0.73) 0.054 (0.002–1.240) 0.068
FIB-4 1.787 (1.344–2.377) < 0.001 0.89 (0.84–0.95) 1.771 (0.821–3.822) 0.145
NFS 3.114 (1.805–5.370) < 0.001 0.93 (0.88–0.97) 2.337 (0.999–5.467) 0.0502.533 (1.451–4.423) 0.050

*Model 1 used M2BPGi, APRI, FIB-4, and NFS as independent variables; †Model 2 selected significant variables by a stepwise method using M2BPGi, APRI, FIB-4, and NFS as independent variables.

Abbreviations: APRI, aspartate aminotransferase to platelet ratio index; CI, confidence interval; F, fibrosis; FIB-4, fibrosis index based on four factors; M2BPGi, Mac-2 binding protein glycosylation isomer; NAFLD, non-alcoholic fatty liver disease; NFS, NAFLD fibrosis score.

Ann Lab Med 2021;41:302~309 https://doi.org/10.3343/alm.2021.41.3.302

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