pISSN 2234-3806eISSN 2234-3814
Table. 4.
Comparison of plasma biomarkers versus urinary biomarkers at ICU admission for MAKE and AKI
| Biomarkers at ICU admission (events: MAKE/AKI) | MAKE | AKI | ||
|---|---|---|---|---|
| AUC (95% CI) | AUC (95% CI) | |||
| Plasma NGAL vs. urinary NGAL | 0.77 (0.60–0.94); | 0.771 | 0.73 (0.53–0.93); | 0.729 |
| (N = 8 of 98 patients/N = 7 of 98 patients) | 0.73 (0.54–0.93) | 0.77 (0.62–0.92) | ||
| 1-plasma hepcidin-25 |
0.60 (0.41–0.78); | 0.010 | 0.63 (0.42–0.84); | 0.103 |
| (N = 9 of 99 patients/N = 9 of 99 patients) | 0.83 (0.72–0.94) | 0.80 (0.68–0.92) | ||
| Plasma IL-6 vs. urinary IL-6 | 0.74 (0.51–0.96); | 0.712 | 0.69 (0.46–0.91); | > 0.99 |
| (N = 4 of 89 patients/N = 4 of 89 patients) | 0.70 (0.42–0.97) | 0.69 (0.46–0.99) | ||
*Indicates biomarker with inverse relationship to endpoints.
Abbreviations: AKI, acute kidney injury; AUC, area under the ROC curve; ICU, intensive care unit; IL, interleukin; MAKE, major adverse kidney events; NGAL, neutrophil gelatinase-associated lipocalin.
Ann Lab Med 2021;41:357~365 https://doi.org/10.3343/alm.2021.41.4.357
© Ann Lab Med