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Table. 4.

Table. 4.

Comparison of AUC values of ROC curves for % maximal dd-DNA/UCr, SCr, UPtn/UCr, and their combinations

AUC (95% CI) Cut-off* Sensitivity (%) Specificity (%) Positive predictive value (%) Negative predictive value (%)
%dd-DNA/UCr 0.58 (0.42–0.75) 47.50% 53.6 77.8 15.2 95.7
SCr (mg/dL) 0.79 (0.60–0.98) 1.3 78.3 83.3 0.58 96.6
UPtn/UCr 0.78 (0.57–0.98) 58.4 57.9 100.0 33.3 100.0
SCr and UPtn/UCr 0.91 (0.76–1.00) 0.2 86.7 100.0 60.0 97.7
%dd-DNA/UCr, SCr and UPtn/UCr 0.93 (0.81–1.00) 0.2 86.7 100.0 60.0 100.0

*The cut-off values for %dd-DNA/UCr, SCr, and UPtn/UCr were individually selected to yield the highest Youden index, whereas the cut-offs for their combinations were determined using a non-parametric general linear model. The diagnostic performance of %dd-DNA/UCr, evaluated by ROC curve analysis, were values of maximal %dd-DNA/UCr, which is defined as the highest %dd-DNA/UCr level among serial %dd-DNA/UCr values measured for each recipient (in both the AR and non-AR groups) at a certain time point.

Abbreviations: AUC, area under the curve; ROC, receiver operating characteristic; CI, confidence interval; dd-DNA, donor-derived DNA; UCr, urine creatinine; SCr, serum creatinine; UPtn, spot urine protein.

Ann Lab Med 2021;41:469~478 https://doi.org/10.3343/alm.2021.41.5.469

© Ann Lab Med