OPEN ACCESS pISSN 2234-3806
eISSN 2234-3814

Table. 1.

Table. 1.

Informative SNVs and variant allele frequency distributions of 39 recipients according to days post-transplantation

Recipient number N informative SNVs* Outcome Days after transplantation % VAF of informative SNVs Mean depth
KT01 11 Non-AR 28 0.315 8,156
105 0.262 13,898
168 1.476 10,231
KT02 7 Non-AR 168 0.885 11,317
196 6.545 9,866
KT03 11 AR 14 2.008 7,338
21 15.189 234
35 1.798 12,158
KT04 10 Non-AR 28 7.863 3,872
56 14.164 1,481
112 19.335 290
168 28.726 953
196 60.878 798
KT05 10 AR 14 18.449 687
28 60.199 859
98 41.693 1,059
KT06 6 Non-AR 21 0.15 1,170
84 0.22 1,181
224 27.358 379
KT07 16 AR 7 10.279 6,257
28 14.012 3,574
56 16.531 2,002
84 6.016 10,501
KT08 13 AR 14 71.87 215
49 74.835 7,369
140 74.182 6,140
168 87.5 667
KT09 12 Non-AR 7 22.247 200
14 3.045 9,065
KT10 6 Non-AR 14 12.29 253
28 3.69 5,120
168 60.259 953
196 50.038 2,836
KT11 7 Non-AR 56 15.27 198
168 53.733 197
196 66.709 570
KT12 13 Non-AR 21 0.747 16,881
63 1.112 21,639
112 0.541 17,665
196 1.772 7,821
KT13 3 Non-AR 21 7.485 2,917
98 1.096 12,332
140 6.866 6,218
KT14 15 Non-AR 7 6.55 7,994
35 60.226 184
84 18.166 1,129
196 71.989 299
KT15 4 Non-AR 7 9.766 1,083
14 1.482 3,149
21 1.729 9,980
28 1.589 16,213
84 1.274 10,194
112 4.617 5,072
168 3.48 10,687
196 3.642 9,194
KT16 5 AR 7 47.212 4,863
14 30.175 11,197
28 38.849 326
KT17 6 Non-AR 7 14.444 1,131
14 0.877 10,340
21 1.427 8,684
28 0.545 9,756
56 0.279 8,548
KT18 14 Non-AR 14 14.217 1,374
21 7.008 2,124
56 6.775 986
168 10.675 544
KT19 10 Non-AR 21 7.199 6,390
28 15.113 2,201
56 21.449 9,504
140 30.468 1,179
168 24.242 690
KT20 6 Non-AR 14 5.373 7,910
28 2.724 6,112
56 10.671 4,680
84 7.544 1,307
KT21 11 Non-AR 14 1.104 6,741
21 0.773 6,372
28 1.302 6,693
56 2.892 3,462
112 1.416 1,820
140 2.39 1,972
168 2.231 1,138
KT22 10 AR 7 37.995 595
28 2.386 7,236
35 5.667 1,772
KT23 7 Non-AR 21 57.325 443
28 9.601 694
56 44.057 3,159
140 12.425 1,103
168 26.747 164
KT24 12 Non-AR 7 0.779 7,900
14 20.215 212
KT25 6 Non-AR 21 31.853 1,733
28 76.37 1,202
56 39.785 529
98 11.965 1,084
140 34.996 155
168 67.116 358
KT26 14 Non-AR 7 4.451 2,753
21 3.166 6,206
28 1.564 577
56 7.804 5,964
168 6.526 3,915
196 27.5 117
KT27 13 Non-AR 21 75.125 4,275
28 70.905 861
56 47.568 179
84 69.772 575
112 62.085 319
140 55.039 1,018
KT28 18 Non-AR 7 73.252 4,460
21 51.656 298
28 71.759 2,175
49 68.115 2,853
84 69.13 2,829
112 70.321 1,243
140 64.442 6,659
KT29 16 Non-AR 7 81.141 1,448
14 87.269 156
KT30 19 Non-AR 7 59.978 215
21 83.587 607
KT31 10 Non-AR 7 3.449 15,343
14 3.683 2,645
KT32 12 Non-AR 7 1.42 4,315
14 9.069 314
KT33 11 AR 7 22.03 7,999
21 5.062 19,788
56 4.564 20,496
KT34 7 Non-AR 14 9.213 293
21 6.532 13,266
28 9.941 2,271
56 10.483 5,422
KT35 9 Non-AR 14 10.816 517
28 11.187 2,630
56 23.901 177
84 17.485 271
KT36 14 Non-AR 14 27.191 814
28 14.659 1,620
56 18.461 201
KT37 13 AR 14 14.544 2,919
21 14.918 3,103
56 28.527 1,219
63 22.442 2,787
KT38 10 Non-AR 7 45.796 156
28 14.405 159
KT39 10 AR 14 2.542 7,328
28 49.321 402
35 4.727 499

*The following 39 SNV markers were used for the chimerism calculation: rs3738561, rs6480497, rs4757113, rs7983800, rs3745331, rs10426644, rs2540307, rs1358833, rs62270249, rs1436501, rs9386037, rs2159478, rs11023112, rs6589967, rs8022985, rs1202017, rs645107, rs6921313, rs4072990, rs6676162, rs72735619, rs11187560, rs10832201, rs7950719, rs6590643, rs1731550, rs10777988, rs4496026, rs12327492, rs1348784, rs281544, rs6445350, rs3819864, rs6863833, rs1423013, rs1561681, rs73230060, rs6995506, and rs16904057.

Abbreviations: SNV, single-nucleotide variant; VAF, variant allele frequency; AR, acute rejection, including acute antibody-mediated rejection and T cell-mediated rejection.

Ann Lab Med 2021;41:469~478 https://doi.org/10.3343/alm.2021.41.5.469

© Ann Lab Med