Main studies and findings on the prognostic role of CRP level in COVID-19 severity
Reference | Study design | Cut-off | Sample size | Main findings |
---|---|---|---|---|
Zeng, |
Meta-analysis | NS | 2,984 patients for assessing severity 393 for assessing mortality | CRP levels increased in severe and fatal COVID-19 patients. |
Qin, |
Retrospective | NS | 452 | CRP levels were significantly higher in patients with severe COVID-19 than in patients with non-severe disease [57.9 (20.9–103.2) mg/L vs. 33.2 (8.2–59.7) mg/L]. |
Liu, |
Retrospective | 8 mg/L | 140 | CRP levels could effectively assess disease severity and predict outcome in COVID-19 patients. |
Wang, |
Cross-sectional | 64.79 mg/L | 143 | CRP levels above the cut-off value were associated with a high risk of progression of COVID-19 to a critical stage. |
Luo, |
Retrospective | 41.4 mg/L | 298 | Increased CRP levels on hospital admission correlated with disease severity, representing a good predictor of adverse outcome. |
Gao, |
Retrospective | NS | 43 | CRP levels showed poor accuracy for predicting severe disease (AUC = 0.60, 95% CI = 0.44–0.75) |
Ahnach, |
Retrospective | 10 mg/L | 145 | CRP levels measured on admission showed good accuracy for predicting severity (AUC = 0.87). The CRP level was an independent predictor of disease severity in multivariate analysis. |
Luo, |
Retrospective | NS | 25 | CRP levels were not associated with severe COVID-19 pathology. CRP levels were not associated with disease severity. |
Villard, |
Retrospective | NS | 44 | CRP levels were significantly higher in patients with a severe clinical course [152 (34–389) mg/L] than in those with a mild or moderate course [83 (3–298) mg/L; |
Yang, |
Retrospective | 26.3 mg/L | 108 | The CRP level showed good prognostic accuracy in assessing the severity of COVID-19 (AUC = 0.79, 95% CI = 0.70–0.86, |
Xie, |
Retrospective | 27.8 mg/L | 140 | Increased CRP levels (median = 76.5 mg/L) were associated with low oxygen saturation (≤ 90%) |
Abbreviations: AUC, area under the curve; COVID-19, coronavirus disease 2019; CRP, C-reactive protein; CI, confidence interval; NS, not specified.
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