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Table. 5.

Table. 5.

Distribution of inhibition zone diameters at the first readable time in fluconazole DDT using two inocula for 188 Candida isolates

Method/species N of results at the following zone diameter (mm) Total N Distance* Overlaps

6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 ≥27
DDT using the standard (0.5 McFarland) inoculum
C. albicans (FS) 1 2 2 2 2 10 7 33 59 −8 27
C. albicans (FR) 2 1 1 1 1 1 7
C. glabrata (F-SDD) 1 3 2 1 11 5 5 5 1 2 36 3 0
C. glabrata (FR) 32 1 33
C. parapsilosis (FS) 1 1 1 2 3 6 15 1 0
C. parapsilosis (FR) 1 1 4 1 3 2 1 1 1 15
C. tropicalis (FS) 1 1 2 5 1 1 5 16 −1 2
C. tropicalis (FR) 3 1 1 1 1 1 8
DDT using the large (2.5 McFarland) inoculum
C. albicans (FS) 3 2 3 3 6 5 6 4 27 59 13 0
C. albicans (FR) 7 7
C. glabrata (F-SDD) 1 1 2 1 4 6 5 6 2 3 2 2 1 36 5 0
C. glabrata (FR) 32 1 33
C. parapsilosis (FS) 1 2 2 6 3 14 5 0
C. parapsilosis (FR) 5 5 4 1 15
C. tropicalis (FS) 1 2 2 4 2 1 4 16 1 0
C. tropicalis (FR) 2 3 2 1 8

*Distance between the ranges for the wild-type and those for the FR variant populations for each species. A negative value indicates overlap between the two populations. The number of overlaps is calculated as the number of wild-type and FR variant isolates for which inhibition zone diameters were overlapping for each species.

Gray boxes indicate zone diameter breakpoints (mm) for FS, F-SDD, or FR in each species, according to the CLSI M60-ED2 document [16].

Abbreviations: DDT, disk diffusion testing; FR, fluconazole resistant; FS, fluconazole susceptible; F-SDD, fluconazole-susceptible dose-dependent.

Ann Lab Med 2021;41:559~567

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