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Table. 3.

Table. 3.

Agreement rates between 12 SARS-CoV-2 antibody (total or IgG) assays using 139 samples from 49 COVID-19 patients

CLIA EIA* LFIA sVNT




Abbott Siemens Roche Euroimmun Vircell Biorad Boditech SD biosensor PCL Sugentech Rapigen GenScript
CLIA Abbott 87.8% 95.7% 80.7% 89.0% 83.5% 90.6% 93.5% 87.8% 92.8% 93.5% 87.8%
0.702 0.883 0.563 0.714 0.544 0.739 0.827 0.679 0.809 0.827 0.628
Siemens 90.6% 89.9% 83.5% 74.3% 85.6% 87.1% 89.9% 86.3% 85.6% 84.2%
0.772 0.784 0.621 0.393 0.642 0.686 0.759 0.671 0.651 0.586
Roche 86.2% 92.7% 85.3% 92.1% 92.1% 92.1% 92.8% 93.5% 89.2%
0.688 0.809 0.594 0.779 0.788 0.792 0.809 0.827 0.672
EIA* Euroimmun 86.2% 77.1% 86.2% 79.8% 91.7% 81.7% 80.7% 83.5%
0.673 0.433 0.677 0.545 0.815 0.587 0.563 0.600
Vircell 87.2% 92.7% 86.2% 90.8% 88.1% 89.0% 88.1%
0.589 0.792 0.647 0.768 0.694 0.714 0.636
Biorad 87.2% 80.7% 81.7% 80.7% 83.5% 84.4%
0.605 0.476 0.509 0.476 0.544 0.470
LFIA Boditech 89.9% 91.4% 92.1% 89.9% 91.4%
0.722 0.767 0.784 0.722 0.726
SD biosensor 87.1% 95.0% 92.8% 85.6%
0.663 0.868 0.809 0.569
PCL 90.6% 89.9% 89.9%
0.759 0.738 0.707
Sugentech 96.4% 86.3%
0.905 0.596
Rapigen 85.6%
0.569

*EIAs were tested using 109 samples from 36 patients. Indicates agreement rate. indicates Kappa values.

Abbreviations: CLIA, chemiluminescence immunoassay; EIA, enzyme immunoassay; LFIA, lateral flow immunoassay; sVNT. surrogate viral neutralization test.

Ann Lab Med 2021;41:577~587 https://doi.org/10.3343/alm.2021.41.6.577

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