OPEN ACCESS pISSN 2234-3806
eISSN 2234-3814

Table. 2.

Table. 2.

Examples of reported cases of the hook effect for hormone measurements

Analyte Measured concentration before dilution Actual concentration after serial dilution Reference
Prolactin 164.5 ng/mL 26,000 ng/mL (macroadenoma) Frieze, et al. 2002 [28]
Calcitonin 182 ng/L 450,000 ng/L Schiettecatte, et al. 2016 [193]
Thyroglobulin 3.8 ng/mL 4.6 ng/mL 207,855 ng/mL 140,462 ng/mL Hillebrand, et al. 2020 [194]
HCG Low/normal 5,899,478 mIU/mL (gestational trophoblastic disease) Cormano, et al. 2015 [195]

Abbreviation: HCG, human chorionic gonadotropin.

© Ann Lab Med