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Table. 4.

Table. 4.

Univariate and multivariate Cox regression analyses of prognostic factors of IgAN progression to ESKD (N=281)

Prognostic factors Cox regression univariate analysis Cox regression multivariate analysis


HR 95% CI P HR 95% CI P
Age at biopsy (yr) 0.498
Sex (female) 0.141
Hypertension (+) 2.07 1.45–2.94 < 0.001
Plasma Hb, per 1 g/L greater 0.77 0.71–0.83 < 0.001
Serum Cr, per 1 µmol/L greater 1.57 1.44–1.70 < 0.001 1.25 1.11–1.42 < 0.001
eGFR, per 1 mL/min/1.73 m2 greater 0.96 0.95–0.97 < 0.001 0.98 0.97–0.99 < 0.001
Serum albumin, per 1 g/L greater 0.42 0.33–0.55 < 0.001
Serum IgA, per 1 g/L greater 0.177
Gross hematuria (+) 0.092
Microscopic hematuria (+) 0.608
24-hr urinary protein ( > 1 g/day) 4.21 2.70–6.56 < 0.001 2.88 1.83–4.55 < 0.001
HLA-DRB1*04 (+) 0.268
HLA-DQB1*04 (+) 0.142
HLA-DQB1*05:03 (+) 0.58 0.33–1.02 0.054

Abbreviations: IgAN, IgA nephropathy; Cr, creatinine; ESKD, end-stage kidney disease; eGFR, estimated glomerular filtration rate; HR, hazard ratio; CI, confidence interval.

Ann Lab Med 2022;42:54~62

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