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Table. 3.

Table. 3.

Clinical performances of EliA, QUANTA Flash, and IIFA for diagnosing AARDs

Rheumatology clinic patients (N = 200)

AUC (95% CI) Cut-off value Sensitivity (%) (95% CI) Specificity (%) (95% CI)

EliA 0.917 (0.870-0.952) > 1.0 ratio (manufacturer) 72.4 (63.6–80.0) 90.9 (82.2–96.3)
> 0.56 ratio (adjusted) 82.9 (75.1–89.1) 90.9 (82.2–96.3)
QUANTA Flash 0.911 (0.863-0.947) ≥ 20.0 CU (manufacturer) 77.2 (68.8–84.3) 89.6 (80.6–95.4)
> 9.7 CU (adjusted) 87.8 (80.7–93.0) 85.7 (75.9–92.6)
IIFA 0.862 (0.806-0.906) ≥ 1 : 80 titer 84.6 (76.9–90.4) 80.5 (69.9–88.7)

Total samples (N = 406)

AUC (95% CI) Cut-off value Sensitivity (%) (95% CI) Specificity (%) (95% CI)

EliA 0.930 (0.900-0.953) > 1.0 ratio (manufacturer) 71.5 (62.7–79.3) 94.0 (90.6–96.5)
> 0.52 ratio (adjusted) 83.7 (76.0–89.8) 91.2 (87.2–94.2)
QUANTA Flash 0.915 (0.883-0.940) ≥ 20.0 CU (manufacturer) 76.4 (67.9–83.6) 91.2 (87.2–94.2)
> 9.9 CU (adjusted) 87.0 (80.7–93.0) 83.0 (78.1–87.2)

Abbreviations: AARD, antinuclear antibody-associated rheumatic disease; AUC, area under the ROC curve; CI, confidence interval; CU, chemiluminescent units; IIFA, indirect immunofluorescence assay.

Ann Lab Med 2022;42:63~70

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