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Table. 2.

Table. 2.

Agreement rates between the five SARS-CoV-2 antibody assays

A/B Roche/ Abbott Roche/ Siemens Roche/SD Biosensor Roche/ LG Chem Abbott/ Siemens Abbott/SD Biosensor Abbott/LG Siemens/ SD Biosensor Siemens/LG Chem SD Biosensor/ LG Chem
Positive/Positive (total number) 364 368 371 371 363 366 366 380 378 385
Positive/Negative (total number) 9 5 2 2 7 4 4 0 2 17
Negative/Positive (total number) 6 12 23 31 17 28 36 14 24 9
Negative/Negative (total number) 700 694 683 675 692 682 674 685 675 669
Positive agreement of A to B (%) (95% CI) 98.4 (96.5–99.4) 96.8 (94.5–98.4) 94.2 (91.4–96.3) 92. 3 (78.2–94.7) 95.5 (92.9–97.4) 92.9 (89.9–95.2) 91.0 (87.8–93.6) 96.5 (94.1–98.0) 94.0 (91.2–96.1) 97.8 (95.7-99.0)
Negative agreement of A to B (%) (95% CI) 98.7 (97.6–99.4) 99.3 (98.3–99.8) 99.7 (98.9–100) 99.7 (98.9–100) 99.0 (97.9–99.6) 99.4 (98.5–99.8) 99.4 (98.5–99.8) 100 (99.5–100) 99.7 (98.9–100) 97.5 (96.1-98.6)
Positive agreement of B to A (%) (95% CI) 97.6 (95.5–98.9) 98.7 (96.9–99.6) 99.5 (98.1–99.9) 99.5 (98.1–99.9) 98.1 (96.1–99.2) 98.9 (97.3–99.7) 98.9 (97.3–99.7) 100 (99.0-100) 99.5 (98.1–99.9) 95.8 (93.3-97.5)
Negative agreement of B to A (%) (95% CI) 99.2 (98.2–99.7) 98.3 (97.1–99.1) 96.7 (95.2–97.9) 95.6 (93.8–97.0) 97.6 (96.2–98.6) 96.1 (94.4–97.4) 94.9 (93.0–96.4) 98.0 (96.7–98.9) 96.6 (94.9–97.8) 98.7 (97.5-99.4)
Total agreement (%) (95% CI) 98.6 (97.7–99.2) 98.4 (97.5–99.1) 97.7 (96.6–98.5) 96.9 (95.7–97.9) 97.8 (96.7–98.6) 97.0 (95.8–98.0) 96.3 (95.0–97.3) 98.7 (97.8–99.3) 97.6 (96.5–98.4) 97.6 (96.5-98.4)
Kappa 0.961 0.962 0.946 0.930 0.943 0.934 0.918 0.966 0.942 0.949

Abbreviations: CI, confidence interval; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Ann Lab Med 2022;42:71~78

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