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Table. 3.

Table. 3.

ROC curve analysis and calculated cutoff values for the five SARS-CoV-2 antibody assays

Roche Abbott Siemens SD Biosensor LG Chem
AUC (P) 0.976 (P < 0.001) 0.987 (P < 0.001) 0.984 (P < 0.001) 0.994 (P < 0.001) 0.987 (P < 0.001)
Manufacturer’s cutoff 1.0 COI 1.4 index 1.0 index (NC+0.3) OD 1.0 S/CO
Sensitivity % (95% CI) according to the manufacturer’s cutoff 93.5 (90.6–95.7) 92.2 (90.0–95.3) 95.7 (93.2–97.5) 98.0 (96.1–99.1) 97.0 (94.5–98.2)
Specificity % (95% CI) according to the manufacturer’s cutoff 99.7 (98.9–100) 99.4 (98.5–99.8) 100 (99.5–100) 99.3 (98.3–99.8) 97.5 (95.9–98.4)
Cutoff calculated based on the Youden index 0.19 COI 0.44 index 0.57 index 0.40 OD 1.16 S/CO
Sensitivity % (95% CI) according to the calculated cutoff 96.5 (94.2–98.1) 96.2 (93.9–97.9) 96.7 (94.5–98.2) 97.7 (95.7–99.0) 96.7 (94.5–98.2)
Specificity % (95% CI) according to the calculated cutoff 98.1 (96.8–99.0) 99.0 (97.9–99.6) 99.6 (98.7–99.9) 99.4 (98.5–99.8) 98.0 (96.6–98.9)

Abbreviations: AUC, area under the curve; COI, cutoff index; NC, negative control; OD, optical density; S/CO, signal/cutoff; CI, confidence interval; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Ann Lab Med 2022;42:71~78

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