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Table. 2.

Table. 2.

Number of data points, average absolute PBIAS, and PNR for each test item and instrument according to three data categories

Analyte Instrument Measured data without conversion action* Data before (measured) and after (converted) conversion action
N (%) Average absolute PBIAS (95% CI)§ PNR||
(% PNR)
N (%) Measured results Converted results
Average absolute PBIAS (95% CI)§ PNR
(% PNR)
Average absolute PBIAS (95% CI) PNR
(% PNR)
AST Ci16000 338 (78) 8.1 (7.5–8.6) 1.5 (1.2) 94 (22) 49.6 (48.3–51.0) 64.9 (14.1) 7.1 (5.6–8.6) 3.2 (0.7)
Vista1 0 (0) 432 (100) 11.6 (10.4–12.8) 25.5 (25.5) 7.2 (6.4–8.1) 3.9 (3.9)
Vista2 0 (0) 432 (100) 12.1 (10.8–13.3) 26.6 (26.6) 7.6 (6.7–8.5) 5.1 (5.1)
Vitros 2 (0) 12.5 0.0 (0.0) 430 (100) 9.9 (9.3–10.5) 19.5 (19.4) 4.9 (4.3–5.4) 0.9 (0.9)
ALT Ci16000 401 (93) 5.2 (4.7–5.8) 0.0 (0.0) 31 (7) 104.3 67.7 (4.9) 23.4 29.0 (2.1)
Vista1 0 (0) 432 (100) 31.6 (29.9–33.4) 75.5 (75.5) 9.7 (8.5–10.8) 2.3 (2.3)
Vista2 0 (0) 432 (100) 30.8 (29.2–32.4) 72.5 (72.5) 9.3 (8.2–10.4) 2.5 (2.5)
Vitros 2 (0) 9.3 0.0 (0.0) 430 (100) 14.7 (13.4–16.0) 23.7 (23.6) 9.0 (7.9–10.1) 1.4 (1.4)
ALP Ci16000 98 (23) 5.1 (4.4–5.7) 0.0 (0.0) 334 (77) 12.5 (11.6–13.4) 22.8 (17.6) 4.0 (3.5–4.5) 0.0 (0.0)
Vista1 0 (0) 432 (100) 4.5 (4.1–4.9) 1.2 (1.2) 4.1 (3.6–4.5) 0.0 (0.0)
Vista2 0 (0) 432 (100) 4.6 (4.3–5.0) 1.9 (1.9) 4.2 (3.7–4.7) 0.7 (0.7)
Vitros 0 (0) 432 (100) 9.2 (8.5–9.9) 24.1 (24.1) 7.2 (6.5–7.9) 5.1 (5.1)
ALB Ci16000 372 (86) 2.3 (2.0–2.6) 3.5 (3.0) 60 (14) 16.5 (16.2–16.7) 11.7 (1.6) 4.7 (3.9–5.5) 23.3 (3.2)
Vista1 18 (4) 4.6 27.8 (1.2) 414 (96) 7.3 (6.9–7.6) 58.9 (56.5) 3.5 (3.2–3.8) 12.8 (12.3)
Vista2 18 (4) 5.7 44.4 (1.9) 414 (96) 7.6 (7.2–7.9) 60.4 (57.9) 3.3 (3.0–3.6) 11.4 (10.9)
Vitros 169 (39) 3.0 (2.4–3.5) 6.5 (2.5) 263 (61) 5.3 (4.9–5.7) 17.1 (10.4) 3.3 (2.9–3.7) 8.0 (4.9)
TP Ci16000 372 (86) 1.4 (1.2–1.5) 0.0 (0.0) 60 (14) 9.7 (9.5–9.8) 0.0 (0.0) 1.4 (1.0–1.8) 0.0 (0.0)
Vista1 292 (68) 1.8 (1.6–2.1) 2.7 (1.9) 140 (32) 6.3 (6.1–6.5) 12.9 (4.2) 3.0 (2.6–3.3) 12.9 (4.2)
Vista2 292 (68) 1.5 (1.2–1.7) 1.4 (0.9) 140 (32) 5.3 (5.1–5.5) 7.9 (2.5) 3.1 (2.7–3.4) 8.6 (2.8)
Vitros 290 (67) 1.6 (1.4–1.8) 2.4 (1.6) 142 (33) 5.4 (5.2–5.6) 7.7 (2.5) 2.5 (2.1–2.9) 4.9 (1.6)
Na Ci16000 432 (100) 1.0 (0.9–1.1) 0.9 (0.9) 0 (0)
Vista1 294 (68) 1.0 (0.9–1.1) 3.4 (2.3) 138 (32) 2.9 (2.8–3.0) 2.9 (0.9) 1.1 (0.9–1.2) 3.6 (1.2)
Vista2 294 (68) 1.0 (0.9–1.2) 5.4 (3.7) 138 (32) 3.1 (3.0–3.2) 9.4 (3.0) 1.2 (1.0–1.4) 5.1 (1.6)
Vitros 398 (92) 1.1 (1.0–1.3) 6.5 (6.0) 34 (8) 15.7 55.9 (4.4) 1.0 2.9 (0.2)
K Ci16000 432 (100) 1.1 (0.9–1.2) 0.2 (0.2) 0 (0)
Vista1 432 (100) 2.0 (1.9–2.2) 0.0 (0.0) 0 (0)
Vista2 432 (100) 2.0 (1.9–2.2) 0.7 (0.7) 0 (0)
Vitros 0 (0) 432 (100) 2.1 (1.9–2.3) 3.7 (3.7) 1.4 (1.2–1.6) 0.5 (0.5)
Cl Ci16000 432 (100) 0.9 (0.8–1.0) 0.7 (0.7) 0 (0)
Vista1 4 (1) 3.8 75.0 (0.7) 428 (99) 2.3 (2.2–2.5) 28.0 (27.8) 1.2 (1.0–1.3) 0.9 (0.9)
Vista2 4 (1) 2.4 0.0 (0.0) 428 (99) 2.1 (1.9–2.2) 21.0 (20.8) 1.3 (1.1–1.4) 2.6 (2.5)
Vitros 10 (3) 12.5 20.0 (0.6) 306 (97) 1.3 (1.1–1.4) 3.6 (3.5) 1.2 (1.0–1.4) 2.6 (2.5)
Ca Ci16000 198 (46) 1.6 (1.3–1.8) 2.0 (0.9) 234 (54) 3.6 (3.4–3.8) 10.3 (5.6) 1.8 (1.5–2.0) 2.6 (1.4)
Vista1 0 (0) 432 (100) 4.1 (3.8–4.4) 45.8 (45.8) 1.9 (1.7–2.1) 5.6 (5.6)
Vista2 0 (0) 432 (100) 4.3 (4.0–4.6) 48.4 (48.4) 2.0 (1.8–2.2) 6.3 (6.3)
Vitros 0 (0) 432 (100) 5.7 (5.5–6.0) 66.9 (66.9) 2.1 (1.8–2.3) 8.6 (8.6)
P Ci16000 432 (100) 3.9 (3.6–4.2) 0.0 (0.0) 0 (0)
Vista1 0 (0) 432 (100) 2.9 (2.5–3.2) 0.0 (0.0) 4.4 (4.1–4.7) 0.0 (0.0)
Vista2 0 (0) 432 (100) 3.0 (2.7–3.4) 0.0 (0.0) 4.4 (4.0–4.7) 0.2 (0.2)
Vitros 0 (0) 432 (100) 10.0 (9.5–10.5) 11.3 (11.3) 4.6 (4.1–5.0) 0.2 (0.2)
Chol Ci16000 0 (0) 432 (100) 2.3 (2.0–2.6) 0.0 (0.0) 2.2 (2.0–2.5) 0.0 (0.0)
Vista1 378 (88) 3.0 (2.7–3.4) 0.8 (0.7) 54 (13) 24.4 (24.0–24.7) 3.7 (0.5) 4.1 (3.2–5.1) 0.0 (0.0)
Vista2 378 (88) 2.5 (2.2–2.8) 0.0 (0.0) 54 (13) 20.6 (20.3–20.9) 1.9 (0.2) 3.5 (2.7–4.3) 0.0 (0.0)
Vitros 374 (87) 2.4 (2.1–2.7) 0.0 (0.0) 58 (13) 18.8 (18.5–19.1) 0.0 (0.0) 3.0 (2.0–3.9) 0.0 (0.0)
Cr Ci16000 0 (0) 432 (100) 5.9 (5.3–6.5) 15.8 (15.8) 4.2 (3.7–4.6) 2.5 (2.8)
Vista1 296 (69) 4.1 (3.6–4.7) 5.7 (3.9) 136 (31) 16.0 (15.4–16.6) 27.2 (8.6) 4.9 (3.9–5.9) 5.1 (1.6)
Vista2 296 (69) 3.9 (3.4–4.4) 1.7 (1.2) 136 (31) 14.8 (14.3–15.4) 19.1 (6.0) 4.2 (3.4–5.1) 3.7 (1.2)
Vitros 432 (100) 5.1 (4.6–5.5) 8.1 (8.1) 0 (0)
Average 179 (42) 3.7 6.9 (1.4) 250 (58) 12.8 23.8 (17.5) 4.3 4.6 (2.5)

*Results that showed acceptable comparability to the reference instrument without a converting action. Results with repeated unacceptable comparability to the reference instrument before conversion, but more acceptable comparability after conversion. The number of times the comparability tests were performed over five years with percentage relative to all available tests in parentheses. §95% confidence intervals were calculated only when the number of cases was more than 50. ||The percentage of unacceptable, incomparable data outside the total allowable limits relative to the number of data points. The percentage relative to total tests (N=432) is shown in parentheses, which can be calculated by multiplying by the percentage of each number of times to total available tests. Statistically significant difference between results before and after the conversion action (P<0.0001).

Abbreviations: PBIAS, percent bias; AST, aspartate transaminase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; ALB, albumin; TP, total protein; Na, sodium; K, potassium; Cl, chloride; Ca, calcium; P, phosphate; Chol, cholesterol; Cr, creatinine; PNR, percentage of noncomparable results.

Ann Lab Med 2022;42:150~159 https://doi.org/10.3343/alm.2022.42.2.150

© Ann Lab Med