pISSN 2234-3806eISSN 2234-3814
Table. 4.
Diagnostic performance of URD (%) >20.1% in the derivation and validation cohorts
| Cohort | AUC (95% CI) |
Sensitivity% (95% CI) |
Specificity% (95% CI) |
RBC count | Type of hematuria | %URD |
%URD and proteinuria |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Positive | Negative | Sensitivity (95% CI) | Specificity (95% CI) | Positive | Negative | Sensitivity (95% CI) |
Specificity (95% CI) |
||||||
| Derivation cohort (N=156) | 0.814 (0.744–0.872) |
99.0 (94.6–100) |
50.9 (37.1–64.6) |
20–100/μL (N=99) | Glomerular (N=70) | 70 | 0 | 100 (94.9–100.0) |
20.7 (8.0–39.7) |
20 | 50 | 28.6 (18.4–40.6) |
96.6 (82.2–99.9) |
| Non-glomerular (N=29) | 23 | 6 | 1 | 28 | |||||||||
| ≥100/μL (N=57) | Glomerular (N=31) | 30 | 1 | 96.8 (83.3–99.9) |
84.6 (65.1–95.6) |
12 | 19 | 38.7 (21.9–57.8) |
100 (86.8–100) |
||||
| Non-glomerular (N=26) | 4 | 22 | 0 | 26 | |||||||||
| Validation cohort (N=107) | 0.806 (0.719–0.876) |
89.4 (76.9–96.5) |
63.3 (49.9–75.4) |
20–100/μL (N=57) | Glomerular (N=27) | 26 | 1 | 96.3 (81.0–99.9) |
50 (31.3–68.7) |
8 | 19 | 29.6 (13.8–50.2) |
100 (88.4–100) |
| Non-glomerular (N=30) | 15 | 15 | 0 | 30 | |||||||||
| ≥100/μL (N=50) | Glomerular (N=20) | 16 | 4 | 80.0 (56.3–94.3) |
76.7 (57.7–90.1) |
9 | 11 | 45.0 (23.1–68.5) |
100 (88.4–100) |
||||
| Non-glomerular (N=30) | 7 | 23 | 0 | 30 | |||||||||
The specificity increases when additional criteria of proteinuria are applied and the degree of hematuria is higher.
*%URD >20.1; †%URD >20.1 and proteinuria (≥+2) on strip urinalysis.
Abbreviations: URD, urinary RBC distribution; RBC, red blood cell, CI, confidence interval; AUC, area under the curve.
Ann Lab Med 2022;42:160~168 https://doi.org/10.3343/alm.2022.42.2.160
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