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Table. 4.

Table. 4.

Diagnostic performance of URD (%) >20.1% in the derivation and validation cohorts

Cohort AUC
(95% CI)
Sensitivity%
(95% CI)
Specificity%
(95% CI)
RBC count Type of hematuria %URD* %URD and proteinuria
Positive Negative Sensitivity (95% CI) Specificity (95% CI) Positive Negative Sensitivity
(95% CI)
Specificity
(95% CI)
Derivation cohort (N=156) 0.814
(0.744–0.872)
99.0
(94.6–100)
50.9
(37.1–64.6)
20–100/μL (N=99) Glomerular (N=70) 70 0 100
(94.9–100.0)
20.7
(8.0–39.7)
20 50 28.6
(18.4–40.6)
96.6
(82.2–99.9)
Non-glomerular (N=29) 23 6 1 28
≥100/μL (N=57) Glomerular (N=31) 30 1 96.8
(83.3–99.9)
84.6
(65.1–95.6)
12 19 38.7
(21.9–57.8)
100
(86.8–100)
Non-glomerular (N=26) 4 22 0 26
Validation cohort (N=107) 0.806
(0.719–0.876)
89.4
(76.9–96.5)
63.3
(49.9–75.4)
20–100/μL (N=57) Glomerular (N=27) 26 1 96.3
(81.0–99.9)
50
(31.3–68.7)
8 19 29.6
(13.8–50.2)
100
(88.4–100)
Non-glomerular (N=30) 15 15 0 30
≥100/μL (N=50) Glomerular (N=20) 16 4 80.0
(56.3–94.3)
76.7
(57.7–90.1)
9 11 45.0
(23.1–68.5)
100
(88.4–100)
Non-glomerular (N=30) 7 23 0 30

The specificity increases when additional criteria of proteinuria are applied and the degree of hematuria is higher.

*%URD >20.1; %URD >20.1 and proteinuria (≥+2) on strip urinalysis.

Abbreviations: URD, urinary RBC distribution; RBC, red blood cell, CI, confidence interval; AUC, area under the curve.

Ann Lab Med 2022;42:160~168 https://doi.org/10.3343/alm.2022.42.2.160

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