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Table. 1.

Table. 1.

Clinical characteristics of patients with F. nucleatum, F necrophorum, or F. varium infections

F. nucleatum (N=19) F. necrophorum (N=24) F. varium (N=43) P
Sex 0.376
Male 13 (68) 18 (75) 36 (84)
Female 6 (32) 6 (25) 7 (16)
Age in years 59 (35–76) 27 (19–66) 59 (40–73) <0.001
WBC count, ×109/L 7.53 (0.48–13.15) 14.66 (7.60–19.39) 9.93 (5.27–16.14) <0.001
Clinical specimen type <0.001
Blood 11 (58) 3 (13) 1 (2)
Aspirate from head and neck 4 (21) 18 (75) 0 (0)
Peritoneal fluid 2 (11) 2 (8) 38 (88)
Others* 2 (11) 1 (4) 4 (9)
Comorbidity
DM 4 (21) 1 (4) 6 (14) 0.004
Renal failure 2 (11) 0 (0) 9 (21) 0.077
Heart failure 1 (5) 0 (0) 1 (2) 0.257
Coronary artery disease (myocardial infarction) 0 (0) 0 (0) 5 (12) 0.002
Cerebrovascular disease 0 (0) 0 (0) 1 (2) 0.564
Chronic pulmonary disease 0 (0) 0 (0) 2 (5) 0.102
Malignancy 10 (53) 3 (13) 29 (67) <0.001
Metastasis 2 (11) 1 (4) 6 (14) 0.066
CCI 0/1/≥2 4/2/13 (21/11/68) 19/2/3 (79/8/13) 4/1/38 (9/2/88) <0.001
CRP, mg/L 69.45 (10.21–252.88) 51.59 (3.97–145.87) 94.9 (20.5–204.62) 0.096
Current cancer diagnosis 10 (53) 3 (13) 29 (67) <0.001
Hematologic malignancy 3 (16) 0 (0) 0 (0)
Stomach cancer 1 (5) 2 (9) 3 (7)
Colorectal cancer 1 (5) 1 (4) 22 (51)
Hepatobiliary cancer 3 (16) 0 (0) 3 (7)
Other cancer type 2 (11) 0 (0) 1 (2)
Surgery 7 (37) 5 (21) 38 (88) <0.001
GI tract surgery 3 (16) 2 (8) 32 (74)
Head and neck surgery 2 (11) 3 (13) 0 (0)
Other type of surgery 2 (11) 0 (0) 6 (14)
Antimicrobials prescribed 15 (79) 22 (92) 42 (98) 0.045
Anti-anaerobic agents used 12 (63) 7 (29) 41 (95) <0.001
Days in hospital 16.5 (7–46) 4 (2–14) 28 (9–74) <0.001
Mortality
Seven days 1 (5) 1 (4) 0 (0) 0.739
30 days 2 (11) 1 (4) 3 (7) 0.186
12 months 3 (16) 2 (8) 6 (14) 0.255

Data are presented as number (%) or median (10–90%-tile).

*F. nucleatum isolated from head aspirate and pleural fluid (N=1, each); F. necrophorum isolated from a deep foot wound; F. varium isolated from buttock aspirate, perianal abscess, pleural fluid, and foot tissue (N=1, each). F. nucleatum, ovarian cancer and oral cavity cancer; F. varium, prostate cancer.

Abbreviations: CCI, Charlson comorbidity index; CRP, C-reactive protein; DM, diabetes mellitus; GI, gastrointestinal; WBC, white blood cell.

Ann Lab Med 2022;42:188~195 https://doi.org/10.3343/alm.2022.42.2.188

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