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Table. 4.

Antimicrobial resistance mechanisms of ESBL-producing and fluoroquinolone-resistant isolates according to ST-fimH-serotype

ST-fimH-serotype Antimicrobial resistance mechanism N isolates
ESBL gene QRDR variation in
gyrA parC parE
ST131-fimH30-O25:H4 CTX-M-15 S83L, D87N S80I, E84V I529L 8
CTX-M-14, 27 S83L, D87N S80I, E84V I529L 2
CTX-M-55 S83L, D87N S80I, E84V I529L 2
- S83L, D87N S80I, E84V I529L 1
ST131-fimH41-O16:H5 CTX-M-27 S83L - I529L 2
ST131-fimH99-O25:H4 CTX-M-27 S83L, D87N S80I, E84V I529L 1
ST95-fimH41-O1:H7 CTX-M-14 - - - 1
ST95-fimH27-O2:H4 - S83L, D87Y S80R - 1
ST38-fimH27-O86:H18 CTX-M-14 S83L, D87Y S80I S458A 1
ST38-fimH65-O25:H15 - S83L, D87N S80I, E84V - 1
ST457-fimH145-O11:H25 CTX-M-14 - - - 1
ST12-fimH27-O4:H5 DHA-1 - - - 1
ST1193-fimH64-O75:H5 - S83L, D87N S80I L416F 5
- S83L, D87N - - 2
ST1193-fimH64-O18:H5 - S83L, D87N S80I L416F 1
- S83L, D87N - - 1
ST69-fimH27-O17:H18 - S83L, D87N S80I - 1

Abbreviations: ESBL, extended-spectrum β-lactamase; QRDR, quinolone resistance-determining region; -, not detected; ST: sequence type.
Ann Lab Med 2022;42:203~212 https://doi.org/10.3343/alm.2022.42.2.203

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