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Table. 2.

Table. 2.

Manufacturer-claimed cut-off values for ELF and M2BPGi to predict mild LF (F≤2 by TE) and advanced LF (F≥3 by TE)

Mild LF (N=136)
Cut-off AUC (95% CI) Sensitivity (95% CI) Specificity (95% CI) PLR (95% CI) NLR (95% CI)
ELF <7.7 0.51 (0.43–0.59) 98.5 (94.8–99.8) 0.0 (0.0–20.6) 1.0 (0.9–1.0) N/A
<9.8 0.52 (044–0.61) 88.9 (82.4–93.7) 68.8 (41.3–88.9) 2.8 (1.4–5.9) 0.2 (0.1–0.3)
M2BPGi (COI) <1.0 0.71 (0.63–0.78) 92.6 (86.8–96.4) 50.0 (24.7–75.4) 1.8 (1.1–3.0) 0.1 (0.0–0.3)
<3.0 0.55 (0.47–0.63) 96.3 (91.6–98.8) 0.0 (0.0–20.6) 1.0 (0.9–1.0) N/A
Advanced LF (N=16)*
Cut-off AUC (95% CI) Sensitivity (95% CI) Specificity (95% CI) PLR (95% CI) NLR (95% CI)
ELF ≥7.7 0.51 (0.43–0.59) 100.0 (79.4–100.0) 1.5 (0.2–5.2) 1.0 (0.9–1.0) 0.0 (N/A)
≥9.8 0.79 (0.71–0.85) 68.8 (41.3–88.9) 88.9 (82.4–93.7) 6.2 (3.5–11.1) 0.4 (0.2–0.7)
M2BPGi (COI) ≥1.0 0.71 (0.63–0.78) 50.0 (24.6–75.3) 92.6 (86.9–96.4) 6.8 (3.1–14.7) 0.5 (0.3–0.9)
≥3.0 0.59 (0.50–0.67) 18.8 (4.0–45.6) 98.5 (94.8–99.8) 12.8 (2.3–70.7) 0.8 (0.6–1.0)

*See Supplemental Data Fig. 3.

Abbreviations: ELF, enhanced liver fibrosis; M2BPGi, Mac-2 binding protein glycosylation isomer; LF, liver fibrosis; TE, transient elastography; AUC, area under the curve; CI, confidence interval; PLR, positive likelihood ratio; NLR, negative likelihood ratio; N/A, not available; COI, cut-off index.

Ann Lab Med 2022;42:249~257 https://doi.org/10.3343/alm.2022.42.2.249

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