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Fig. 1.

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Fig. 1. (A) Bone marrow aspirate at initial diagnosis (×1,000 magnification). (B) G-banding karyotyping showing t(11;22)(q23;q13). (C) Schematic representation of the KMT2A-EP300 fusion. (D–F) Fusion between exon 10 of KMT2A and exon 15 of EP300 confirmed by (D) an NGS RNA fusion panel, (E) gel electrophoresis following reverse transcription-PCR (yellow arrow), and (F) Sanger sequencing of complementary DNA.
Abbreviations: MBD, menin-binding domain; NLS, nuclear localization signal; CxxC, motif recognizing unmethylated CpG dinucleotides; PHD, plant homeodomain fingers; TAD, transactivation domain; SET, H3K4 histone methyltransferase domain; TAZ, transcriptional-adaptor zinc-finger domain; CH, cysteine/histidine-rich regions; KIX, kinase-inducible domain of the CREB-interacting domain; BD, bromodomain; KAT, lysine acetyltransferase domain; Pt, patient; NTC, no template control.
Ann Lab Med 2022;42:693~696

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