Fig. 1. Number and distribution of CHIP mutations in the study cohort. (A) Number of CHIP mutations identified using a targeted NGS panel of 49 myeloid malignancy driver genes. (B) The frequency of CHIP mutation increases with age. (C) Forest plot showing the odds ratio with 95% CI for the presence of CHIP mutation according to a 1-year increase in age. (D) Numbers of CHIP mutations per individual. (E) VAFs of CHIP mutations detected in the study cohort. Mutations in DNMT3A, TET2, and other genes are indicated by specific symbols. (F) Distribution of the VAF of CHIP mutations per gene. Dotted lines indicate median VAFs of 2.0%, 2.5%, and 2.0% mutations in DNMT3A, TET2, and other genes, respectively.
Abbreviations: CI, confidence interval; CHIP, clonal hematopoiesis of indeterminate potential; NGS, next-generation sequencing; VAF, variant allele frequency.

Ann Lab Med 2023;43:145~152 https://doi.org/10.3343/alm.2023.43.2.145