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Table. 1.

Recommended NP cut-offs for acute HF diagnosis*

Cut-off to make a decision Cut-off points

BNP, pg/mL NT-proBNP, pg/mL MR-proANP, pmol/L



All ages Aged <50 yr Aged 50–75 yr Aged >75 yr All ages
Acute/acutely decompensated HF
Rule out HF < 100 < 300 < 300 < 300 < 40
Mild probability (“grey” zone) 100–400 300–450 300–900 300–1,800 40–120
Rule in HF > 400 > 450 > 900 > 1,800 > 120
Stable HF
Rule out HF < 35 < 125 < 125 ≥ 125 < 40
Mild probability (“grey” zone) 35–150 125–600 125–600 125–600 40–120
Rule in HF > 150 > 600 > 600 > 600 > 120

*Data were obtained from references [25-29].

Abbreviations: NP, natriuretic peptide; HF, heart failure; BNP, brain natriuretic peptide; NT-proBNP, N-terminal pro-B-type natriuretic peptide; MR-pro-ANP, mid-regional pro-atrial natriuretic peptide.

Ann Lab Med 2023;43:225~236 https://doi.org/10.3343/alm.2023.43.3.225

© Ann Lab Med