Fig. 1. Linearity range and correlation of mutant allele measurement between gravimetric dilution and NGS-MRD tests. (A) KIT c.2447A>T, (B) IDH2 c.515G>A, (C) KRAS c.34G>T, (D) KRAS c.35G>A, (E) KRAS c.183A>C, and (F) NRAS c.182A>G. The results of the linearity analyses using serially diluted reference material ranged from 5.00% to 0.06%. The best-fit regression equation and correlation coefficient (R) for each variant are indicated in the plots.
Abbreviations: NGS, next-generation sequencing; MRD, measurable residual disease.

Ann Lab Med 2023;43:328~336 https://doi.org/10.3343/alm.2023.43.4.328