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Table. 1.

Table. 1.

Baseline characteristics of LDKT and DDKT recipients stratified according to the presence of low-DSA

Characteristics LDKT recipients (N=629) P DDKT recipients (N=398) P


Low-DSA (N=68) No-DSA (N=561) Low-DSA (N=21) No-DSA (N=377)
Patients
Age (yr) 47.0 ± 10.8 45.6 ± 12.0 0.317 53.7 ± 8.8 49.9 ± 9.6 0.080
Female sex, N (%) 47 (69.1) 207 (36.9) < 0.001 14 (66.7) 147 (39.0) 0.012
Etiology of kidney disease, N (%) 0.673 0.866
Diabetes 14 (20.6) 128 (22.8) 5 (23.8) 78 (20.7)
Hypertension 5 (7.4) 52 (9.3) 3 (14.3) 80 (21.2)
Glomerulonephritis 30 (44.1) 205 (36.5) 8 (38.1) 124 (32.9)
Others 19 (27.9) 176 (31.4) 5 (23.8) 95 (25.2)
HLA-A/B/DR mismatches 3.3 ± 1.3 3.0 ± 1.7 0.260 4.0 ± 1.0 3.6 ± 1.5 0.264
PRA I (%) 66.8 ± 32.9 50.6 ± 34.9 0.007 73.9 ± 28.5 52.9 ± 32.7 0.028
PRA II (%) 76.0 ± 26.5 55.4 ± 31.3 0.001 80.4 ± 31.4 51.3 ± 29.5 0.002
PRA > 50%, N (%) 51 (75.0) 88 (15.7) < 0.001 16 (76.2) 61 (16.2) < 0.001
HLA class I 35 (51.5) n.a. 10 (47.6) n.a.
HLA class II 28 (41.2) n.a. 8 (38.1) n.a.
HLA class I+ II 5 (7.4) n.a. 3 (14.3) n.a.
HLA-DSA peak MFI 3,676 (1,903–6,213) n.a. 4,385 (2,608–7,952) n.a.
Pretransplant dialysis, N (%) 47 (69.1) 372 (66.3) 0.643 21 (100.0) 377 (100.0) n.a.
Time on dialysis, months 36.5 ± 52.0 20.0 ± 38.7 0.040 109.1 ± 58.4 88.8 ± 54.7 0.100
Follow-up period, months 47.7 ± 31.8 55.6 ± 31.6 0.051 50.0 ± 27.4 56.7 ± 28.7 0.295
Donors
Age (yr) 41.4 ± 12.5 43.3 ± 12.2 0.211 53.7 ± 8.8 49.9 ± 9.6 0.080
Female sex, N (%) 32 (47.1) 320 (57.0) 0.117 5 (28.6) 128 (34.0) 0.612
Transplants
Retransplant, N (%) 15 (22.1) 45 (8.0) < 0.001 9 (42.9) 28 (7.4) < 0.001
Induction therapy, N (%) < 0.001 0.001
Basiliximab 30 (44.1) 539 (96.1) 6 (28.6) 239 (63.4)
ATG 38 (55.9) 22 (3.9) 15 (71.4) 138 (36.6)
Initial immunosuppression, N (%) 0.236 1.000
Tacrolimus 67 (98.5) 532 (94.8) 21 (100.0) 373 (98.9)
Cyclosporine 1 (1.5) 29 (5.2) 0 (0.0) 4 (1.1)
Desensitization, N (%) < 0.001 < 0.001
No 16 (23.5) 486 (86.6) 7 (33.3) 340 (90.2)
Yes 52 (76.4) 75 (13.4) 14 (66.7) 37 (9.8)

Continuous variables are presented as means±SDs or medians with interquartile ranges. Categorical variables are presented as numbers (proportions).

Abbreviations: ATG, anti-thymocyte globulin; DDKT, deceased donor kidney transplant; HLA-DSA, donor-specific anti-HLA antibody; LDKT, living donor kidney transplant; low-DSA, low-level donor-specific anti-HLA antibody; MFI, mean fluorescence intensity; PRA, panel-reactive antibody; n.a., not applicable.

Ann Lab Med 2023;43:364~374 https://doi.org/10.3343/alm.2023.43.4.364

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