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Table. 3.

Table. 3.

Transplanted culture-positive HSC products and patient outcomes

Case number Diagnosis Sample type Microbial culture Source/step of contamination Prophylactic antibiotics Evidence of infection* Outcome
1 Neuroblastoma, stage IV Auto-PBSC Pseudomonas aeruginosa Collection/processing Teicoplanin, ticarcillin/clavulanic acid, gentamicin Not apparent Engrafted
2 Severe aplastic anemia Allo-BM Corynebacterium jeikeium Culture preparation Acyclovir, cefepime, teicoplanin, micafungin Not apparent Engrafted
3 Acute myeloid leukemia Allo-PBSC Leuconostoc pseudomesenteroides Culture preparation Acyclovir, cefepime, micafungin Not apparent Engrafted
4 Acute myeloid leukemia Allo-PBSC Streptococcus salivarius Culture preparation Acyclovir, voriconazole Not apparent Engrafted

*Evidence of infection was assessed based on body temperature, blood pressure, respiratory rate, pulse rate, and the serum C-reactive protein concentration within 24 hours after infusion.

Abbreviations: HSC, hematopoietic stem cell; PBSC, peripheral blood stem cell; BM, bone marrow.

Ann Lab Med 2023;43:477~484

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