pISSN 2234-3806eISSN 2234-3814
Table. 4.
Performance of the LDH/ULN ratio alone and the modified PLASMIC-S, including LDH/ULN, for the prediction of patients with TMA due to severe ADAMTS13 deficiency assessed to be at high risk
| Scoring system | Sensitivity, % (95% CI) | Specificity, % (95% CI) | NPV, % (95% CI) | PPV, % (95% CI) | Accuracy, % |
|---|---|---|---|---|---|
| LDH/ULN ratio alone (cut-off > 2.0) | 100.0 (91.9–100.0) | 85.2 (76.7–91.4) | 100.0 (95.8–100.0) | 74.6 (61.6–85.0) | 89.7 |
| Modified PLASMIC-S (cut-off > 6) | 81.8 (67.3–91.8) | 97.0 (91.6–99.3) | 92.5 (85.7–96.7) | 92.3 (79.1–98.3) | 92.4 |
Abbreviations: LDH, lactate dehydrogenase; ULN, upper limit of normal (230 IU/L in our study); PLASMIC-S, PLASMIC score; ADAMTS13, a disintegrin and metalloprotease with thrombospondin type 1 motif, member 13; CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value; TMA, thrombotic microangiopathy.
Ann Lab Med 2023;43:485~492 https://doi.org/10.3343/alm.2023.43.5.485
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