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Table. 1.

Table. 1.

Characteristics of the patients and TDM data

Characteristic Value*
N 54
Male sex, N (%) 26 (48.1)
Age, yr 71.5 (59, 81)
≥ 65 yr, N (%) 34 (63.0)
Body weight, kg 56.7 (48.8, 65.0)
Height, cm 160.5 (154.9, 170.0)
BSA, m2 1.58 (1.46, 1.71)
BMI, kg/m2 21.8 (19.6, 24.2)
Albumin, g/L 29 (27, 33)
Complicated infections, N (%) 34 (63.0)
MRSA infections, N (%) 9 (16.7)
Complicated MRSA infections, N (%) 8 (14.8)
Serum creatinine, mg/dL
1st TDM occasion 0.53 (0.45, 0.66)
2nd TDM occasion 0.52 (0.45, 0.67)
eCLcr, mL/min
1st TDM occasion 100 (62, 145)
2nd TDM occasion 97 (69, 137)
eGFR§, mL/min/1.73 m2
1st TDM occasion 104 (86, 119)
2nd TDM occasion 106 (89, 119)
Daily vancomycin dose per weight, mg/kg
1st TDM occasion 30.8 (25.8, 37.7)
2nd TDM occasion 38.0 (24.5, 53.5)
Single vancomycin dose, mg
1st TDM occasion 800 (662.5, 1000)
2nd TDM occasion 650 (600, 800)
Vancomycin dosing interval, N (1st/2nd)
4 hr 1/7
6 hr 2/13
8 hr 7/15
12 hr 41/17
24 hr 3/2
N doses before 1st trough sampling 5 (3.3, 7.8)
Time gap from 1st dose to trough sampling, hr
1st trough sampling 60.0 (47.6, 72.0)
2nd trough sampling 167.8 (132.5, 228.0)
Measured vancomycin trough concentration, mg/L
1st TDM set 11.6 (6.8, 16.8)
2nd TDM set 18.1 (15.1, 20.7)
Measured vancomycin peak concentration, mg/L
1st TDM set 25.9 (21.1, 33.3)
2nd TDM set 26.7 (22.8, 34.6)

*Number (%) or median (Q1, Q3); Complicated infections such as bacteremia, endocarditis, osteomyelitis, and CNS infections including meningitis and pneumonia; Calculated using the Cockcroft–Gault equation; §Calculated using the CKD-EPI equation.

Abbreviations: BMI, body mass index; BSA, body surface area; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; CNS, central nervous system; eCLcr, estimated creatinine clearance; eGFR, estimated glomerular filtration rate; MRSA, methicillin-resistant Staphylococcus aureus; Q1, 25th percentile; Q3, 75th percentile; TDM, therapeutic drug monitoring.

Ann Lab Med 2023;43:554~564 https://doi.org/10.3343/alm.2023.43.6.554

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