Fig. 3. Scatter plots depicting the predicted AUC24 or concentration (using 1^st TDM occasion data) versus reference AUC24 (estimated using 2^nd TDM occasion data) or measured concentration (N=54), respectively. The predicted values were obtained using trough (left; A, C, E, G, I, K) or both trough and peak (right; B, D, F, H, J, L) concentration data. Reference values are AUC_{estimated[T&P]} for (A) and (B); AUC_estimated[T] for (C) and (D); AUC_Eq.(4) for (E) and (F); AUC_Eq.(5) for (G) and (H); trough C_measured for (I) and (J); and peak C_measured for (K) and (L). The dashed lines are the identity lines. The gray lines represent locally estimated scatterplot smoothing curves to assist visual exploration of trends.
Abbreviations: AUC24, area under the concentration-–time curve normalized to 24 hours (mg∙hr/L); TDM, therapeutic drug monitoring.

Ann Lab Med 2023;43:554~564 https://doi.org/10.3343/alm.2023.43.6.554