Fig. 2. Tornado diagram of sensitivity analysis. (A) Tissue-only strategy. (B) Tissue-first strategy. (C) Plasma-first strategy in first-line treatment. (D) Tissue-only strategy. (E) Tissue-first strategy. (F) Plasma-first strategy in second-line treatment. The horizontal bars in the tornado diagrams indicate how wide the variation in the total cost due to a change in a given input is. At the time of first diagnosis, first-generation TKI is the most cost-influential factor. At the time of disease progression, T790M status in tumor tissue is the most cost-influential factor.
Abbreviations: 1st-gen, first-generation; TKI, tyrosine kinase inhibitor.

Ann Lab Med 2023;43:605~613 https://doi.org/10.3343/alm.2023.43.6.605