OPEN ACCESS pISSN 2234-3806
eISSN 2234-3814

Table. 1.

MIC and MBC data for SPR719 against treatment-naive clinical NTM isolates (N=325)

NTM species N of isolates with indicated MIC (µg/mL) MIC range (µg/mL) MIC50 (µg/mL) MIC90 (µg/mL)
0.031 0.062 0.125 0.25 0.5 1 2 4 8 16 >16
Mycobacterium avium (N=63) 1 (2) 10 (16) 33 (52) 14 (22) 2 (3) 3 (5) 0.125−16 2 4
M. intracellulare (N=58) 1 (2) 11 (19) 32 (55) 5 (9) 7 (12) 2 (3) 0.25−8 1 4
M. kansasii (N=58) 16 (28) 30 (52) 4 (7) 2 (3) 2 (3) 1 (2) 2 (3) 1 (2) 0.031−16 ≤0.062 0.25
M. abscessus (N=65)* 1 (2) 2 (3) 15 (23) 29 (44) 16 (25) 2 (3) 0.125−8 2 4
M. massiliense (N=67) 6 (9) 10 (15) 17 (25) 21 (31) 10 (15) 3 (5) 0.062−4 1 2
M. fortuitum (N=14) 1 (7) 1 (7) 4 (29) 3 (21) 3 (21) 2 (15) 0.25−8 2 8
N of isolates with indicated MBC (µg/mL) MBC range (µg/mL) MBC50 (µg/mL) MBC90 (µg/mL)
0.031 0.062 0.125 0.25 0.5 1 2 4 8 16 >16
M. avium (N=63) 1 (2) 8 (13) 32 (50) 11 (18) 3 (5) 4 (6) 4 (6) 0.125−16 2 16
M. intracellulare (N=58) 1 (2) 3 (5) 18 (31) 23 (39) 5 (9) 3 (5) 5 (9) 0.25−16 2 8
M. kansasii (N=58) 11 (19) 24 (41) 12 (20) 4 (7) 3 (5) 1 (2) 1 (2) 1 (2) 1 (2) 0.031−16 0.062 0.5
M. abscessus (N=65)* 1 (2) 4 (6) 19 (29) 31 (47) 9 (14) 1 (2) 0.5−16 4 8
M. massiliense (N=67) 1 (2) 1 (2) 3 (4) 16 (23) 30 (45) 15 (22) 1 (2) 0.062−8 2 4
M. fortuitum (N=14) 2 (14) 2 (14) 4 (29) 1 (7) 5 (36) 0.5−8 2 8

Data are presented as number (%). *42 of 65 M. abscessus isolates showed inducible resistance in phenotypic drug susceptibility testing.

Abbreviations: MIC, minimum inhibitory concentration; MIC50, minimum concentration required to inhibit 50% of bacteria; MIC90, minimum concentration to inhibit 90% of bacteria; MBC, minimum bactericidal concentration; MBC50, minimum concentration required to kill 50% of bacteria; MBC90, minimum concentration required to kill 90% of bacteria; NTM, nontuberculous mycobacteria.

© Ann Lab Med