MIC and MBC data for SPR719 against treatment-naive clinical NTM isolates (N=325)
NTM species | N of isolates with indicated MIC (µg/mL) | MIC range (µg/mL) | MIC50 (µg/mL) | MIC90 (µg/mL) | ||||||||||
0.031 | 0.062 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | >16 | ||||
1 (2) | 10 (16) | 33 (52) | 14 (22) | 2 (3) | 3 (5) | 0.125−16 | 2 | 4 | ||||||
1 (2) | 11 (19) | 32 (55) | 5 (9) | 7 (12) | 2 (3) | 0.25−8 | 1 | 4 | ||||||
16 (28) | 30 (52) | 4 (7) | 2 (3) | 2 (3) | 1 (2) | 2 (3) | 1 (2) | 0.031−16 | ≤0.062 | 0.25 | ||||
1 (2) | 2 (3) | 15 (23) | 29 (44) | 16 (25) | 2 (3) | 0.125−8 | 2 | 4 | ||||||
6 (9) | 10 (15) | 17 (25) | 21 (31) | 10 (15) | 3 (5) | 0.062−4 | 1 | 2 | ||||||
1 (7) | 1 (7) | 4 (29) | 3 (21) | 3 (21) | 2 (15) | 0.25−8 | 2 | 8 | ||||||
N of isolates with indicated MBC (µg/mL) | MBC range (µg/mL) | MBC50 (µg/mL) | MBC90 (µg/mL) | |||||||||||
0.031 | 0.062 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | >16 | ||||
1 (2) | 8 (13) | 32 (50) | 11 (18) | 3 (5) | 4 (6) | 4 (6) | 0.125−16 | 2 | 16 | |||||
1 (2) | 3 (5) | 18 (31) | 23 (39) | 5 (9) | 3 (5) | 5 (9) | 0.25−16 | 2 | 8 | |||||
11 (19) | 24 (41) | 12 (20) | 4 (7) | 3 (5) | 1 (2) | 1 (2) | 1 (2) | 1 (2) | 0.031−16 | 0.062 | 0.5 | |||
1 (2) | 4 (6) | 19 (29) | 31 (47) | 9 (14) | 1 (2) | 0.5−16 | 4 | 8 | ||||||
1 (2) | 1 (2) | 3 (4) | 16 (23) | 30 (45) | 15 (22) | 1 (2) | 0.062−8 | 2 | 4 | |||||
2 (14) | 2 (14) | 4 (29) | 1 (7) | 5 (36) | 0.5−8 | 2 | 8 |
Data are presented as number (%). *42 of 65
Abbreviations: MIC, minimum inhibitory concentration; MIC50, minimum concentration required to inhibit 50% of bacteria; MIC90, minimum concentration to inhibit 90% of bacteria; MBC, minimum bactericidal concentration; MBC50, minimum concentration required to kill 50% of bacteria; MBC90, minimum concentration required to kill 90% of bacteria; NTM, nontuberculous mycobacteria.
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