Table. 2. Table 2

MIC and MBC data for SPR719 against clarithromycin-resistant and amikacin-resistant clinical NTM isolates

NTM species	N of isolates with indicated MIC (µg/mL)											MIC range (µg/mL)	MIC₅₀ (µg/mL)	MIC₉₀ (µg/mL)
NTM species	0.031	0.062	0.125	0.25	0.5	1	2	4	8	16	>16	MIC range (µg/mL)	MIC₅₀ (µg/mL)	MIC₉₀ (µg/mL)
Clarithromycin-resistant isolates (N=57)
Mycobacterium avium (N=10)					3 (30)	2 (20)	3 (30)	1 (10)	1 (10)			0.5–8	1	8
M. intracellulare (N=17)		1 (6)			3 (18)	6 (35)	3 (17)	2 (12)	2 (12)			0.062–8	1	8
M. abscessus (N=13)		1 (8)			2 (15)	6 (47)	2 (15)	2 (15)				0.062–4	1	4
M. massiliense (N=17)		2 (12)	1 (6)	4 (23)	4 (23)	2 (12)	2 (12)	2 (12)				0.062–4	0.5	4
Amikacin-resistant isolates (N=44)
M. avium (N=12)						7 (59)	4 (33)		1 (8)			1–8	1	2
M. intracellulare (N=17)					4 (24)	6 (35)	5 (29)	2 (12)				0.5–4	1	4
M. abscessus (N=9)						1 (11)	7 (78)	1 (11)				1–4	2	4
M. massiliense (N=6)					3 (50)	2 (33)	1 (17)					0.5–2	0.5	2
	N of isolates with indicated MBC (µg/mL)											MBC range (µg/mL)	MBC₅₀ (µg/mL)	MBC₉₀ (µg/mL)
	0.031	0.062	0.125	0.25	0.5	1	2	4	8	16	>16	MBC range (µg/mL)	MBC₅₀ (µg/mL)	MBC₉₀ (µg/mL)
Clarithromycin-resistant isolates (N=57)
M. avium (N=10)					2 (20)	2 (20)	4 (40)	1 (10)	1 (10)			0.5–8	2	8
M. intracellulare (N=17)				1 (6)	2 (12)	5 (29)	5 (29)	2 (12)	1 (6)	1 (6)		0.25–16	1	8
M. abscessus (N=13)							3 (23)	6 (46)	4 (31)			2–8	4	8
M. massiliense (N=17)				4 (23)	2 (12)	3 (18)	3 (18)	5 (29)				0.25–4	1	4
Amikacin-resistant isolates (N=44)
M. avium (N=12)						6 (50)	4 (34)	1 (8)	1 (8)			1–8	1	4
M. intracellulare (N=17)					1 (6)	6 (35)	7 (41)	1 (6)	2 (12)			0.5–8	2	8
M. abscessus (N=9)							1 (11)	7 (78)	1 (11)			2–8	4	8
M. massiliense (N=6)						4 (67)	2 (33)					1–2	1	2

Data are presented as number (%).

Abbreviations: MIC, minimum inhibitory concentration; MIC₅₀, minimum concentration required to inhibit 50% of bacteria; MIC₉₀, minimum concentration to inhibit 90% of bacteria; MBC, minimum bactericidal concentration; MBC₅₀, minimum concentration required to kill 50% of bacteria; MBC₉₀, minimum concentration required to kill 90% of bacteria; NTM, nontuberculous mycobacteria.

Ann Lab Med 2024;44:92~96 https://doi.org/10.3343/alm.2024.44.1.92