pISSN 2234-3806eISSN 2234-3814
Table. 3.
Predictive performances of biomarkers for AKI and mortality
| Biomarker | AUC (95% CI) | Cutoff value | Sensitivity | Specificity | ||
|---|---|---|---|---|---|---|
| Predictive value of each biomarker on admission for the occurrence of AKI during ICU stay | ||||||
| uLFABP | 0.70 (0.67–0.72) | 38.6 ng/mL | 0.63 | 0.66 | - | - |
| uNGAL | 0.79 (0.76–0.81) | 214.1 ng/mL | 0.74 | 0.78 | <0.001 | - |
| uCysC | 0.64 (0.62–0.67) | 0.40 mg/L | 0.61 | 0.64 | <0.001 | - |
| pNGAL | 0.81 (0.79–0.83) | 244.5 ng/mL | 0.74 | 0.78 | <0.001 | 0.004 |
| pCysC | 0.82 (0.80–0.84) | 1.43 mg/L | 0.74 | 0.79 | <0.001 | <0.001 |
| Combination | ||||||
| uLFABP + uNGAL | 0.80 (0.77–0.81) | - | 0.74 | 0.73 | <0.001 | - |
| uLFABP + uCysC | 0.70 (0.67–0.72) | - | 0.69 | 0.64 | 0.810 | - |
| uLFABP + uNGAL + uCysC | 0.79 (0.77–0.81) | - | 0.74 | 0.74 | <0.001 | - |
| Predictive value of each biomarker on admission for 28-day mortality | ||||||
| uLFABP | 0.63 (0.59–0.66) | 42.8 ng/mL | 0.58 | 0.61 | - | - |
| uNGAL | 0.66 (0.63–0.70) | 247.0 ng/mL | 0.62 | 0.64 | 0.007 | - |
| uCysC | 0.55 (0.52-0.59) | 0.37 mg/L | 0.56 | 0.54 | <0.001 | - |
| pNGAL | 0.68 (0.65–0.71) | 265.5 ng/mL | 0.63 | 0.65 | 0.001 | 0.160 |
| pCysC | 0.68 (0.64–0.71) | 1.44 mg/L | 0.67 | 0.65 | 0.007 | <0.001 |
| Combination | ||||||
| uLFABP + uNGAL | 0.67 (0.64–0.70) | - | 0.62 | 0.64 | 0.003 | - |
| uLFABP + uCysC | 0.59 (0.56–0.63) | - | 0.58 | 0.58 | 0.004 | - |
| uLFABP + uNGAL + uCysC | 0.68 (0.65–0.71) | - | 0.62 | 0.63 | 0.002 | - |
| Predictive value of each biomarker at discharge for 1-yr mortality | ||||||
| uLFABP | 0.57 (0.51–0.63) | 8.5 ng/mL | 0.63 | 0.49 | - | - |
| uNGAL | 0.64 (0.58–0.69) | 61.3 ng/mL | 0.64 | 0.61 | 0.014 | - |
| uCysC | 0.57 (0.51–0.63) | 0.13 mg/L | 0.56 | 0.55 | 0.990 | - |
| pNGAL | 0.66 (0.59–0.72) | 163.5 ng/mL | 0.58 | 0.72 | 0.014 | 0.520 |
| pCysC | 0.50 (0.44–0.57) | 1.24 mg/L | 0.52 | 0.51 | 0.130 | 0.160 |
| Combination | ||||||
| uLFABP + uNGAL | 0.61 (0.55–0.67) | - | 0.53 | 0.66 | 0.038 | - |
| uLFABP + uCysC | 0.57 (0.51–0.63) | - | 0.63 | 0.47 | 0.930 | - |
| uLFABP + uNGAL + uCysC | 0.61 (0.55–0.67) | - | 0.55 | 0.63 | 0.050 | - |
*vs. AUC of uLFABP using the DeLong test.
†vs. AUC of the same biomarker in urine using the DeLong test.
Abbreviations: AUC, area under the ROC curve; ICU, intensive care unit; AKI, acute kidney injury; uLFABP, urinary liver fatty acid-binding protein; uNGAL, urinary neutrophil gelatinase-associated lipocalin; uCysC, urinary cystatin C; pNGAL, plasma neutrophil gelatinase-associated lipocalin; pCysC, plasma cystatin C.
Ann Lab Med 2024;44:144~154 https://doi.org/10.3343/alm.2023.0083
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