OPEN ACCESS pISSN 2234-3806
eISSN 2234-3814

Table. 3.

Table. 3.

Predictive performances of biomarkers for AKI and mortality

Biomarker AUC (95% CI) Cutoff value Sensitivity Specificity P* P
Predictive value of each biomarker on admission for the occurrence of AKI during ICU stay
uLFABP 0.70 (0.67–0.72) 38.6 ng/mL 0.63 0.66 - -
uNGAL 0.79 (0.76–0.81) 214.1 ng/mL 0.74 0.78 <0.001 -
uCysC 0.64 (0.62–0.67) 0.40 mg/L 0.61 0.64 <0.001 -
pNGAL 0.81 (0.79–0.83) 244.5 ng/mL 0.74 0.78 <0.001 0.004
pCysC 0.82 (0.80–0.84) 1.43 mg/L 0.74 0.79 <0.001 <0.001
Combination
uLFABP + uNGAL 0.80 (0.77–0.81) - 0.74 0.73 <0.001 -
uLFABP + uCysC 0.70 (0.67–0.72) - 0.69 0.64 0.810 -
uLFABP + uNGAL + uCysC 0.79 (0.77–0.81) - 0.74 0.74 <0.001 -
Predictive value of each biomarker on admission for 28-day mortality
uLFABP 0.63 (0.59–0.66) 42.8 ng/mL 0.58 0.61 - -
uNGAL 0.66 (0.63–0.70) 247.0 ng/mL 0.62 0.64 0.007 -
uCysC 0.55 (0.52-0.59) 0.37 mg/L 0.56 0.54 <0.001 -
pNGAL 0.68 (0.65–0.71) 265.5 ng/mL 0.63 0.65 0.001 0.160
pCysC 0.68 (0.64–0.71) 1.44 mg/L 0.67 0.65 0.007 <0.001
Combination
uLFABP + uNGAL 0.67 (0.64–0.70) - 0.62 0.64 0.003 -
uLFABP + uCysC 0.59 (0.56–0.63) - 0.58 0.58 0.004 -
uLFABP + uNGAL + uCysC 0.68 (0.65–0.71) - 0.62 0.63 0.002 -
Predictive value of each biomarker at discharge for 1-yr mortality
uLFABP 0.57 (0.51–0.63) 8.5 ng/mL 0.63 0.49 - -
uNGAL 0.64 (0.58–0.69) 61.3 ng/mL 0.64 0.61 0.014 -
uCysC 0.57 (0.51–0.63) 0.13 mg/L 0.56 0.55 0.990 -
pNGAL 0.66 (0.59–0.72) 163.5 ng/mL 0.58 0.72 0.014 0.520
pCysC 0.50 (0.44–0.57) 1.24 mg/L 0.52 0.51 0.130 0.160
Combination
uLFABP + uNGAL 0.61 (0.55–0.67) - 0.53 0.66 0.038 -
uLFABP + uCysC 0.57 (0.51–0.63) - 0.63 0.47 0.930 -
uLFABP + uNGAL + uCysC 0.61 (0.55–0.67) - 0.55 0.63 0.050 -

*vs. AUC of uLFABP using the DeLong test.

vs. AUC of the same biomarker in urine using the DeLong test.

Abbreviations: AUC, area under the ROC curve; ICU, intensive care unit; AKI, acute kidney injury; uLFABP, urinary liver fatty acid-binding protein; uNGAL, urinary neutrophil gelatinase-associated lipocalin; uCysC, urinary cystatin C; pNGAL, plasma neutrophil gelatinase-associated lipocalin; pCysC, plasma cystatin C.

Ann Lab Med 2024;44:144~154 https://doi.org/10.3343/alm.2023.0083

© Ann Lab Med