Fig. 3. Guidance for assessing hematological toxicity after CAR T-cell therapy. In the CAR-HEMATOTOX model, low platelet count, high ferritin level, low absolute neutrophil count, low Hb level, and high CRP level are risk factors for hematologic toxicity. Based on the sum of scores, high or low risk can be determined. Based on the ICAHT grading system, early and late ICAHT can be determined according to the time after CAR T-cell infusion.
Abbreviations: CAR, chimeric antigen receptor; ICAHT, immune effector cell-associated hematotoxicity; EHA, European Hematology Association; EBMT, European Society for Blood and Marrow Transplantation; CRP, C-reactive protein; ANC, absolute neutrophil count.

Ann Lab Med 2024;44:210~221 https://doi.org/10.3343/alm.2023.0388