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Table. 5.

Table. 5.

Recommendations for result interpretation and reporting

Recommendation Grade of recommendation Level of evidence
Result interpretation
It may be considered to assess somatic variants based on clinical and biological interpretation. B I
It is recommended to conduct clinical interpretation in the context of the tumor type of the patient. A I
It is recommended to consider the possibility of false positives and clonal hematopoiesis of indeterminate potential when interpreting variants. A I
If germline pathogenic variants are suspected, it may be considered to sequence normal, matched samples as a confirmation test and provide genetic counseling to the patient. B I
Result reporting
It is recommended that the report includes essential information for clinical decision-making and is concise. A I
It is recommended to report general associations of variants and therapeutic options rather than specific recommendations. A I
It is recommended to acknowledge the possibility of false negatives as a limitation when a variant is not detected. A I
It may be considered to mention negative findings in actionable genes in a tumor-specific manner. B I
Ann Lab Med 2024;44:195~209 https://doi.org/10.3343/alm.2023.0389

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