pISSN 2234-3806
eISSN 2234-3814

Table. 5. Table 5

Recommendations for result interpretation and reporting

Recommendation	Grade of recommendation	Level of evidence
Result interpretation
It may be considered to assess somatic variants based on clinical and biological interpretation.	B	I
It is recommended to conduct clinical interpretation in the context of the tumor type of the patient.	A	I
It is recommended to consider the possibility of false positives and clonal hematopoiesis of indeterminate potential when interpreting variants.	A	I
If germline pathogenic variants are suspected, it may be considered to sequence normal, matched samples as a confirmation test and provide genetic counseling to the patient.	B	I
Result reporting
It is recommended that the report includes essential information for clinical decision-making and is concise.	A	I
It is recommended to report general associations of variants and therapeutic options rather than specific recommendations.	A	I
It is recommended to acknowledge the possibility of false negatives as a limitation when a variant is not detected.	A	I
It may be considered to mention negative findings in actionable genes in a tumor-specific manner.	B	I