OPEN ACCESS pISSN 2234-3806
eISSN 2234-3814

Table. 1.

Table. 1.

Comparison of methods for direct LDL-C assay and estimated equations for LDL-C with a reference method

Group Variable Ultracentrifugation* dLDL-C Friedewald Martin–Hopkins Sampson
Group 1 (TG≥400 mg/dL) Median (IQR) 148 (116–177) 149 (130–170) 85 (59–112) 121 (101–142) 101 (81–122)
P 0.7745 <0.0001 <0.0001 <0.0001
Bias (%) 0.5 −42.4 −18.5 −31.7
Group 1a (TG=400–500 mg/dL) Median (IQR) 151 (115–180) 149 (122–174) 93 (61–124) 126 (101–151) 106 (78–132)
P 0.4070 <0.0001 <0.0001 <0.0001
Bias (%) −1.5 −38.4 −16.6 −30.1
Group 1b (TG=500–900 mg/dL) Median (IQR) 148 (124–174) 148 (132–165) 77 (55–98) 114 (102–134) 98 (82–112)
P 0.8201 <0.0001 <0.0001 <0.0001
Bias (%) −0.2 −48.3 −22.7 −34.0
Group 2 (LDL-C≤70 mg/dL) Median (IQR) 58 (49–62) 61 (54–68) 41 (34–46) 45 (37–50) 43 (36–48)
P <0.0001 <0.0001 <0.0001 <0.0001
Bias (%) 5.3 −29.6 −22.9 −25.4
Group 2a (LDL-C=10–40 mg/dL) Median (IQR) 49 (44–54) 55 (51–63) 34 (29–38) 36 (30–41) 36 (29–40)
P <0.0001 <0.0001 <0.0001 <0.0001
Bias (%) 10.9 −31.8 −25.8 −26.7
Group 2b (LDL-C=40–70 mg/dL) Median (IQR) 62 (58–66) 65 (61–69) 46 (43–49) 49 (46–53) 48 (45–51)
P <0.0001 <0.0001 <0.0001 <0.0001
Bias (%) 5.8 −25.1 −20.2 −21.9

*Reference method.

Abbreviations: IQR, interquartile range; TG, triglycerides; LDL-C, low-density-lipoprotein cholesterol; dLDL-C, direct LDL-C assay.

Ann Lab Med 2024;44:363~366 https://doi.org/10.3343/alm.2023.0387

© Ann Lab Med