pISSN 2234-3806eISSN 2234-3814
Table. 1.
Characteristics of individuals with weak D types 1, 2, 3, 4.0, 4.1, and Asian-type DEL and guidance for Rho(D) immune globulin administration
| RhD type | Designation | ISBT nomenclature |
Molecular variant(s) |
Prevalent ethnicity | Serologic testing | Transfusion recommendation | Rh immunoprophylaxis in pregnancy | ||
|---|---|---|---|---|---|---|---|---|---|
| Anti-D reagent |
Weak D test |
Adsorption/ elution test |
|||||||
| Weak D types 1, 2, 3, 4.0, 4.1 | Weak D type 1 | RHD*01W.1 RHD*weak D type 1 |
c.809T>G | European Americans | Negative | Positive | Positive | D-positive blood units are possible | Unnecessary |
| Weak D type 2 | RHD*01W.2 RHD*weak D type 2 |
c.1154G>C | European Americans | Negative | Positive | Positive | D-positive blood units are possible | Unnecessary | |
| Weak D type 3 | RHD*01W.3 RHD*weak D type 3 |
c.8C>G | European Americans | Negative | Positive | Positive | D-positive blood units are possible | Unnecessary | |
| Weak D type 4.0 | RHD*09.03 RHD*DAR3 |
c.602C>G c.667T>G |
African Americans | Negative | Positive | Positive | D-positive blood units are possible | Unnecessary | |
| Weak D type 4.1 | RHD*09.04 RHD*DAR4 |
c.602C>G c.667T>G c.819G>A |
African Americans | Negative | Positive | Positive | D-positive blood units are possible | Unnecessary | |
| Asian-type DEL | RHD (1227G>A) | RHD*01EL.01 RHD*DEL1 |
c.1227G>A | East Asians | Negative | Negative | Positive | D-positive blood units are possible | Unnecessary |
Abbreviation: ISBT, International Society of Blood Transfusion.
Ann Lab Med 2024;44:307~313 https://doi.org/10.3343/alm.2023.0356
© Ann Lab Med