Fig. 3. Comparison of thyroid function at diagnosis. (A–C) Comparison of serum FT3, FT4, and TSH levels at diagnosis between patients with TSHR biallelic variants and those with the TSHR monoallelic variant. The number of patients carrying TSHR biallelic or monoallelic variants is seven and 18, respectively. (D–F) Comparison of serum FT3, FT4, and TSH levels at diagnosis between patients with biallelic TSHR or DUOX2 variants. The number of patients carrying TSHR or DUOX2 biallelic variants is seven and 81, respectively. The Mann–Whitney U test was used to compare serum FT4 and TSH levels between the two groups, and serum FT3 levels at diagnosis were compared between the two groups using Student’s t-test. *P<0.05, ***P<0.001.
Abbreviations: TSH, thyroid-stimulating hormone; TSHR, TSH receptor; FT3, free triiodothyronine; FT4, free thyroxine; ns, no significance.

Ann Lab Med 2024;44:343~353 https://doi.org/10.3343/alm.2023.0337