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Table. 3. Mutations in oprD, carbapenemase genes, expression of ampC, and carbapenem MICs in carbapenem-non-susceptible Pseudomonas aeruginosa isolates
No. isolate ST Frameshift mutation in oprD
(predicted amino acids [N]*)
Carbapenemase gene Expression of ampC MIC (µg/mL)
Imipenem Meropenem
KBN10P02278 111 + (0) - 2.0 32 16
KBN12P02599 111 + (241) - 0.8 16 4
KBN06P05035 111 + (441) - 1.2 8 0.5
KBN06P06750 111 + (414) - 1.6 128 16
KBN10P06128 235 + (224) blaVIM-2 1.2 256 128
KBN10P06311 235 + (93) blaIMP-6 1.3 16 >256
KBN12P04564 235 + (93) blaIMP-6 5.7 8 >256
KBN06P03632 235 + (224) blaVIM-2 4.5 128 64
KBN06P03793 235 + (93) blaIMP-6 1.4 64 >256
KBN10P04040 244 + (235) - 17.2 16 16
KBN06P05117 244 + (355) - 9.5 64 16
KBN06P02912 245 + (344) - 32.9 32 16
KBN06P03210 245 + (344) - 32.8 32 8
KBN06P02359 245 + (344) - 37.5 64 16
KBN12P06040 357 + (52) - 0.2 32 32
KBN10P06125 622 + (354) - 14.7 16 64
KBN06P06881 622 + (93) blaIMP-6 0.5 64 >256
KBN12P06387 1015 + (235) - 1.1 16 64
KBN10P03382 1154 + (224) - 10.2 64 16

*Nucleotide sequences of oprD in clinical isolates were compared with those of P. aeruginosa PAO1. OprD of P. aeruginosa PAO1 has 443 amino acids.

Overexpression of ampC in clinical isolates.

Abbreviations: ST, sequence type; MIC, minimum inhibitory concentration.

Ann Lab Med 2024;44:410~417 https://doi.org/10.3343/alm.2023.0369

© Ann Lab Med